Abstract
Susceptibility to inorganic mercuric ions and to organomercurials of 237 Pseudomonas aeruginosa clinical strains isolated in Mexico was determined by agar dilution tests. Resistant strains fell into two classes: i) narrow-spectrum resistant strains (27% of total isolates) resistant only to mercuric ions and to merbromin, and most grouped in pyocin type 1; and ii) broad-spectrum resistant strains (5%) with additional resistances to thimerosal, phenylmercury, methylmercury and p-hydroxymercuribenzoate, that belonged mostly to pyocin type 10. Mercurial resistant isolates showed a higher proportion of resistance to antibiotics and metals than did mercurial sensitive isolates, and broad-spectrum resistant strains had the highest frequency of resistance to antibiotics and to tellurite and arsenate.
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References
Cenci, G., G. Morozzi, F. Scazzocchio & A. Morosi (1982) Antibiotic and metal resistance of Escherichia coli isolates from different environmental sources. Zentralblatt fur Bakteriologie und Hygiene (Abteilung I, Originale C) 3: 440–449
Cervantes-Vega, C., J. Chávez & M. G. Rodríguez (1986) Antibiotic susceptibility of clinical isolates of Pseudomonas aeruginosa. Antonie van Leeuwenhoek 52: 319–324
Cowan, S. T. (1974) Cowan and Steel's manual for the identification of medical bacteria, 2nd edn. Cambridge University Press, Cambridge
Ericsson, H. M. & J. C. Sherris (1971) Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathologica Microbiologica Scandinavica (Section B Supplement) 217: 1–90
Govan, J. R. W. (1978) Pyocin-typing of Pseudomonas aeruginosa. In: T. Bergan & J. R. Norris (Eds) Methods in Microbiology 10: 61–91 Academic Press, London
Groves, D. J. & F. E. Young (1975) Epidemiology of antibiotic and heavy metal resistance in bacteria: resistance patterns in staphylococci isolated from populations not known to be exposed to heavy metals. Antimicrobial Agents and Chemotherapy 7: 614–621
Hall, B. M. (1970) Mercury resistance of Staphylococcus aureus. Journal of Hygiene 68: 121–129
Khesin, R. B. & E. V. Karasyova (1984) Mercury-resistant plasmids in bacteria from a mercury and antimony deposit area. Mol. Gen. Genet. 197: 280–285
Nakahara, H., T. Ishikawa, Y. Sarai, I. Kondo & S. Mitsuhashi (1977a) Frequency of heavy-metal resistance in bacteria from inpatients in Japan. Nature (London) 266: 165–167
Nakahara, H., T. Ishikawa, Y. Sarai, I. Kondo, H. Kozukue & S. Silver (1977b) Linkage of mercury, cadmium, and aresenate and drug resistance in clinical isolates of Pseudomonas aeruginosa. Applied and Environmental Microbiology 33: 975–976
Nelson, J. D., W. Blair, F. E. Brinckman, R. R. Colwell & W. P. Iverson (1973) Biodegradation of phenylmercuric acetate by mercury-resistant bacteria. Applied Microbiology 26: 321–326
Novick, R. P. & C. Roth (1968) Plasmid-linked resistance to inorganic salts in Staphylococcus aureus. J. Bacteriol. 95: 1335–1342
Porter, F. D., S. Silver, C. Ong & H. Nakahara (1982) Selection for mercurial resistance in hospital settings. Antimicrobial Agents and Chemotherapy 22: 852–858
Robinson, J. B. & O. H. Tuovinen (1984) Mechanisms of microbial resistance and detoxification of mercury and organomercurial compounds: physiological, biochemical, and genetic analyses. Microbiological Reviews 48: 95–124
Silver, S. (1981) Mechanisms of plasmid-determined heavy metal resistances. In: S. B. Levy, R. C. Clowes & E. L. Koenig (Eds) Molecular Biology, Pathogenicity and Ecology of Bacterial Plasmids (pp. 179–189) Plenum Press, New York
Summers, A. O., G. A. Jacoby, M. N. Swartz, G. McHugh and L. Sutton (1978) Metal cation and oxyanion resistances in plasmids of gram-negative bacteria. In: D. Schlessinger, (Ed) Microbiology-1978 (pp. 128–131) American Society for Microbiology, Washington, DC
Timoney, J. F., J. Port, J. Giles & J. Spanier (1978) Heavy-metal and antibiotic resistance in the bacterial flora of sediments of New York Bight. Applied and Environmental Microbiology 36: 465–472
Walker, J. D. & R. R. Colwell (1974) Mercury-resistant bacteria and petroleum degradation. Applied Microbiology 27: 285–287
Weiss, A. A., J. L. Schottel, D. L. Clark, R. G. Beller & S. Silver (1978) Mercury and organomercurial resistance with enteric, staphylococcal, and pseudomonad plasmids. In: D. Schlessinger (Ed) Microbiology-1978 (pp. 121–124) American Society for Microbiology, Washington, DC
Witte, W., N. Van Dip & R. Hummel (1980) Resistance against mercury and cadmium in Staphylococcus aureus of different ecological origin. Zeitschrift für Allgemeine Mikrobiologie 20: 517–521
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Cervantes-Vega, C., Chávez, J. Susceptibility to mercurials of clinical Pseudomonas aeruginosa isolated in México. Antonie van Leeuwenhoek 53, 253–259 (1987). https://doi.org/10.1007/BF00393932
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DOI: https://doi.org/10.1007/BF00393932