Summary
A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21;p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtained at a recombination value of 0.05 for a linkage between HLA and the breakpoint, indicating that the chromosomal region, carrying the HLA genes, is situated near the breakpoint in band 6p21 close to the transition to 6p22.
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Breuning, M.H., van den Berg-Loonen, E.M., Bernini, L.F. et al. Localization of HLA on the short arm of chromosome 6. Hum Genet 37, 131–139 (1977). https://doi.org/10.1007/BF00393575
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DOI: https://doi.org/10.1007/BF00393575