Summary
The levels of IgE antibodies specific for toluene-diisocyanate (TDI), diphenylmethane-diisocyanate (MDI) and hexamethylene-diisocyanate (HDI) were determined in eight workers with an unequivocal history of professional asthma, all having been exposed to isocyanates in the working atmosphere. Five workers were examined at the clinical onset of asthma. They had serum IgE antibodies specific for TDI, MDI and HDI, and depressed pulmonary ventilation parameters. In contrast, three workers, who had only a mild bronchial obstruction at the time of testing, had no anti-isocyanate IgE antibodies. The results indicated that asthma was induced by type I allergic reaction, but other pathogenetic mechanisms of bronchoobstruction could not be completely ruled out.
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Bagon DA, Hardy HL (1978) Determination of free monomeric toluene diisocyanate (TDI) and 4,4-diisocyanatediphenylmethane (MDI) in TDI and MDI prepolymers, respectively, by high-performance liquid chromatography. J Chromatogr 152:560–564
Baur X, Dewair M, Rommelt H (1984) Acute airway obstruction followed by hypersensitivity pneumonitis in an isocyanate (MDI) worker. J Occup Med 26:285–287
Belin L, Waas U, Audunsson G, Mathiasson L (1983) Amines: possible causative agents in the development of bronchial hyperreactivity in workers manufacturing polyurethanes from isocyanates. Br J Ind Med 40:251–257
Burge PS, O'Brien IM, Harries MG (1979) Peak flow rate records in the diagnosis of occupational asthma due to isocyanates. Thorax 344:317–323
Chai H, Farr RS, Froehlich LA, Mathiason DA, McLean JA, Rosenthal RR, Sheffler AL, Sheldon LS, Townley RG (1975) Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 56:323–327
Commision des communautes europennes C.E.C.A. (1967) Tabeles de references pour les examens spirographeques. Luxemburg
Cvitanović S, Marušić M, Zekan LJ, Köhler-Kubelka N (1986) Allergy induced by Parietaria officinalis pollen in Southern Croatia. Allergy 41:543–545
Fabbri LM, Boschetto P, Zocca E, Milani G, Pivirotto F, Plebani M, Burlina A, Licata B, Mapp C (1988) Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate. Am Rev Respir Dis 136:36–42
Ferris BG Jr, Anderson DO, Zickmantel R (1965) Prediction values for screening tests of pulmonary function. Am Rev Respir Dis 91:252–261
Karol MH (1981) Survey of industrial workers for antibodies to toluene diisocyanate. J Occup Med 23:741–747
Karol MH, Alarie YC (1980) Antigens which detect IgE antibodies in workers sensitive to toluene diisocyanate. Clin Allergy 10:101–109
Karol MH, Hauth B (1982) Use of hexyl isocyanate antigen to detect antibodies to hexamethylene diisocyanate (HDI) in sensitized guinea pigs and in a sensitized worker. Fundam Appl Toxicol 2:108–113
Karol MH, Ioset HH, Alarie YC (1978) Tolyl-specific IgE antibodies in workers with hypersensitivity to toluene diisocyanate. Am Ind Hyg Assoc J 39:454–458
Karol MH, Sandberg T, Riley EJ, Alarie YC (1979) Longitudinal study of tolyl-reactive IgE antibodies in workers hypersensitive to TDI. J Occup Med 21:354–358
Malo JL, Zeiss CR (1982) Occupational hypersensitivity pneumonitis after exposure to diphenylmethane diisocyanate. Am Rev Respir Dis 125:113–116
Pepys J, Pickering CAC, Breslin ABX, Terry DJ (1972) Asthma due to inhaled chemical agents - tolylene diisocyanate. Clin Allergy 2:225–236
Pezzini A, Riviera A, Paggiaro P, Spiazzi A, Gerosa F, Filieri M, Toma G, Tridente G (1984) Specific IgE antibodies in twenty-eight workers with diisocyanate-induced bronchial asthma. Clin Allergy 14:453–461
Tse KS, Johnson A, Chan H, Chan-Yeung M (1985) A study of serum antibody activity in workers with occupational exposure to diphenylmethane diisocyanate. Allergy 40:314–320
Welinder H, Nielsen J, Bensryd I, Skerfving S (1988) IgG antibodies against polyisocyanates in car painters. Clin Allergy 18:85–93
White WG, Sugden E, Morris MJ, Zapata E (1980) Isocyanate induced asthma in a car factory. Lancet 1:756–760
Zammit-Tabona M, Sherkin M, Kijek K, Chan H, ChanYeung M (1983) Asthma caused by diphenylmethane diisocyanate in foundry workers. Am Rev Respir Dis 128:226–230
Zedda S, Cirla A, Aresini G, Sala C (1976) Occupational type test for the etiological diagnosis of asthma due to toluene diisocyanate. Respiration 33:14–21
Zeiss CR, Kanellakes T, Bellone J, Levitz D, Pruzansky JJ, Patterson R (1979) IgG and IgE antibody in two workers with diphenylmethane diisocyanate-induced respiratory disease. J Allergy Clin Immunol 63:150–155
Zeiss CR, Kanellakes TM, Bellone JD, Levitz D, Pruzansky JJ, Patterson R (1980) Immunoglobulin Emediated asthma and hypersensitivity pneumonitis with precipitating anti-hapten antibodies due to diphenylmethane diisocyanate (MDI) exposure. J Allergy Clin Immunol 65:346–352
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Cvitanović, S., Zekan, L. & Marušić, M. Occurrence and specificity of IgE antibodies to isocyanates in occupationally exposed workers. Int. Arch Occup Environ Heath 61, 483–486 (1989). https://doi.org/10.1007/BF00386483
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DOI: https://doi.org/10.1007/BF00386483