Summary
Biochemical markers of kidney damage were examined in 37 female workers exposed to an average concentration of 225 mg/m3 of styrene. The concentration of mandelic acid in urine was on the average 759 mg/g creatinine. The mean duration of employment of the exposed subjects was 11 years. The results were compared to those obtained in 35 control female workers matched for age and a number of demographic and lifestyle factors and with no history of exposure to organic solvents. No difference was found in the urinary excretion of albumin, beta2-microglobulin, retinol-binding protein, total proteins, glucose, lysozyme, lactate dehydrogenase and beta-N-acetyld-glucosaminidase. The present study provides thus further evidence that exposure to styrene at the current TLV (215 mg/m3) does not entail any detectable risk for the renal function.
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References
Askergren A, Allgren LG, Karlsson C, Lundberg I, Nyberg E (1981) Studies on kidney functions in subjects exposed to organic solvents. I. Excretion of albumin and β2-microglobulin in the urine. Acta Med Scand 209:479–483
Bernard AM, Lauwerys RR (1983) Continuous flow-system for automatin of latex immunoassay by particle counting. Clin Chem 29:1007–1011
Franchini I, Cavatorta A, Falzoi M, Lucertini S, Mutti A (1983) Early indicators of renal damage in workers exposed to styrene. Int Arch Occup Environ Health 52:1–9
Henry RJ, Cannon DC, Winhelman JW (1974) Clinical chemistry: principles and technics. 2nd Ed. Harper and Row, New York, pp 552–554
Litwack G (1955) Photometric determination of lysozyme activity. Proc Soc Exp Biol Med 39:401–403
Sedivec V, Flek J (1970) Bestimmung toxischer Substanzen und ihrer Metaboliten in biologischen Flüssigkeiten mittels der GLC. IV. Mandelsäure im Urine. Collect Czech Chem Comm 35:931–937
Tucker SM, Boyd PJR, Thompson AE, Price RG (1975) Automated assay of N-acetyl-beta-glucosaminidase in normal and pathological urine. Clin Chim Acta 62:333–339
Viau C, Bernard A, de Russis R, Ouled A, Maldague P, Lauwerys R (1987) Evaluation of the nephrotoxic potential of styrene in man and in rat. J Appl Toxicol 7:313–316
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Vyskocil, A., Emminger, S., Malir, F. et al. Lack of nephrotoxicity of styrene at current TLV level (50 ppm). Int Arch Occup Environ Heath 61, 409–411 (1989). https://doi.org/10.1007/BF00381033
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DOI: https://doi.org/10.1007/BF00381033