Summary
The urinary excretion of 3,4-dimethylhippuric acid (34DMHA), a 1,2,4-trimethylbenzene (124TMB) metabolite, was investigated in workers exposed to 124TMB vapor. The time-weighted average of exposure to 124TMB was determined with a diffusive sampler. For biological monitoring of exposure, urine samples were collected from individual workers and analyzed for metabolites by high-pressure liquid chromatography. The concentration of urinary 34DMHA had a positive correlation with the level of exposure to 124TMB (r = 0.72). The data suggest that 34DMHA is one of the useful indicators for biological monitoring of 124TMB exposure.
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References
American Conference of Governmental Industrial Hygienists (1987) Threshold limit value and biological exposure indices for 1986–1987. ACGIH, Cincinnati
Cerf J, Potvin M, Laham S (1980) Acidic metabolites of pseudocumene in rabbit urine. Arch Toxicol 45:93–100
Huo J, Aldous S, Campbell K, Davies N (1989) Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat. Xenobiotica 19:161–170
Japan Association of Industrial Health (1991) Recommended occupational exposure limits (in Japanese). Jpn J Ind Health 33:277–298
Mikulski PI, Wiglusz R (1975) The comparative metabolism of mesitylene, pseudocumene, and hemimellitene in rats. Toxicol Appl Pharmacol 31:21–31
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Ichiba, M., Hama, H., Yukitake, S. et al. Urinary excretion of 3,4-dimethylhippuric acid in workers exposed to 1,2,4-trimethylbenzene. Int. Arch Occup Environ Heath 64, 325–327 (1992). https://doi.org/10.1007/BF00379541
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DOI: https://doi.org/10.1007/BF00379541