Summary
Serum parathyroid hormone (PTH) and renal functions were measured in thirty subjects with cadmium-induced renal damage and in the same number of control subjects. The negative correlations between PTH and creatinine clearance (Ccr) and between PTH and percentage renal phosphorus reabsorption (% TRP) were significant in the cadmium (Cd)-exposed group. Serum PTH concentrations were clearly high in two cases of the cadmium-exposed group. Their renal functions decreased severely compared with those of the other Cd-exposed people. The present study indicates that chronic cadmium intoxication could cause increased secretions of PTH, which may be related to cadmium-induced bone damage.
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Bernard A, Buchet JP, Roels H, Masson P, Lauwerys (1979) Renal excretion of proteins and enzymes in workers exposed to cadmium. Eur J Clin Invest 9:11–22
Brickman AS, Coburn JW, Massry SG, Norman AW (1974) 1.25-dihydroxy vitamin D in normal man and patients with renal failure. Ann Int Med 80:160–168
Fujita T., Ohno J, (1973) The kidney and calcium. Ishiyaku Shuppan Co., Tokyo [in Japanese]
Furukawa Y, Yumita S, Son T, Umiue H (1980) Radioimmunoassay of plasma parathyroid hormone by PTH assay Kit (EIKEN). Clin Endocrinol 28:583–589 [in Japanese]
Fuss M, Backer MO, Brauman J, Niss-Dewoef N, Manderlier T, Brauman H, Corvilaiv J (1976) Parathyroid hormone plasma level in untreated chronic renal failure and in hemodialyzed patients. Nephron 17:144–154
Honda R, Kobayashi E, Nogawa K, Sakamoto M (1981) Urinary excretion of cadmium, copper, calcium and phosphorus in the general population in Ishikawa Prefecture. J Kanazawa Med Uni 6:26–33 [in Japanese]
Ishikawa Prefecture Department of Health (1976) Results of the epidemiological study on the health effects of cadmium on the population in the Kakehashi River basin. Kanazawa [in Japanese]
Kajikawa K, Kitagawa M, Nakanishi I, Ueshima H, Katsuda S, Kuroda K (1974) A pathological study of itai-itai disease. J Juzen Med Soc 83:309–347 [in Japanese]
Kato T, Nakagawa S, Kitagawa M (1982) Follow-up studies on itai-itai patients, persons requiring observation and patients who died. Kankyo Hoken Report 48:139–148 [in Japanese]
Kitagawa M (1982) Record of autopsy of itai-itai patient in Toyama Prefecture. Kankyo Hoken Report 48:204–206 [in Japanese]
Kobayashi E, Honda R, Tsuritani I, Nogawa K (1981) Urinary excretions of protein, glucose, amino acids, proline and β 2-microglobulin in the general population in Ishikawa Prefecture. J Kanazawa Med Univ 6:76–84 [in Japanese]
Mawer EB, Backhouse J, Taylor CM, Lumb GA (1973) Failure of formation of 1.25-(OH)2D3 in chronic renal failure. Lancet 1:626–628
Mukawa A, Nogawa K, Hagino N (1980) Bone biopsy performed on women living in the Cd polluted Jinzu River basin. Jap J Hyg 35:761–773 [in Japanese]
Nogawa K (1981) Itai-itai disease and follow-up studies. In: Nriagu JO (ed) Cadmium in the environment. John Wiley & Sons Inc, New York, pp 1–37
Nogawa K, Kobayashi E, Honda R, Ishizaki A, Kawano S, Matsuda H (1980) Renal dysfun tions of inhabitants in a cadmium-polluted area. Environ Res 23:13–23
Ohnishi T, Morimoto S, Tsuji M, Okada Y, Kumahara Y (1979) Radioimmunoassay for par thyroid hormone and its clinical application. Clin Endocrinol 27:1299–1302 [in Japanese]
Reiss E, Canterbury JM, Kanter A (1969) Circulating parathyroid hormone concentration chronic renal insufficiency. Arch Int Med 124:417–422
Tsuchiya K (1978) Cadmium studies in Japan. A review. Kodansha and Elsevier/North-Hc land Biomedical Press, Tokyo Amsterdam
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Nogawa, K., Kobayashi, E., Yamada, Y. et al. Parathyroid hormone concentration in the serum of people with cadmium-induced renal damage. Int. Arch Occup Environ Heath 54, 187–193 (1984). https://doi.org/10.1007/BF00379048
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DOI: https://doi.org/10.1007/BF00379048