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Parathyroid Hormone Dysfunction

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PanVascular Medicine

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Abstract

Phosphorus-calcium homeostasis is regulated by parathyroid hormone (PTH). A primary (parathyroid gland adenoma or hyperplasia) or secondary (chronic renal failure or vitamin D deficiency) excess of this hormone or a PTH defect (hypoparathyroidism) has deleterious effects on the heart and vascular system. In this chapter the different disorders and their effects on the cardiovascular system are reviewed.

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Abbreviations

FGF23/klotho system :

is a system that maintains phosphate homeostasis.

Fibroblast growth factor-23 (FGF23):

is secreted from bone, and it promotes phosphate excretion.

Klotho:

is a membrane-bound protein expressed in renal tubules and an obligate co-receptor to activate FGF receptors.

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Authors and Affiliations

  1. Endocrinology and Nutrition Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Av Marítima del Sur s/n, 35016, Las Palmas de Gran Canaria, Spain

    Rosa M. Sánchez & Ana María Wägner

  2. Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

    Rosa M. Sánchez & Ana María Wägner

Authors
  1. Rosa M. Sánchez
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  2. Ana María Wägner
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Correspondence to Rosa M. Sánchez .

Editor information

Editors and Affiliations

  1. Division of Cardiovascular Disease Department of Internal Medicine, Health Care Center Bitterfeld, Bitterfeld-Wolfen, Germany

    Peter Lanzer

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© 2015 Springer-Verlag Berlin Heidelberg

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Sánchez, R.M., Wägner, A.M. (2015). Parathyroid Hormone Dysfunction. In: Lanzer, P. (eds) PanVascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37078-6_175

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  • DOI: https://doi.org/10.1007/978-3-642-37078-6_175

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37077-9

  • Online ISBN: 978-3-642-37078-6

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