Summary
The rate of incorporation of phosphate precursor into phospholipids in vivo has been investigated in normal rats and in those intoxicated with CS2. The specific activity of 32p phospholipids was measured in plasma and the aorta wall at various times after i.v. administration of 0.2 mCi phosphate.
In CS2 intoxicated rats the specific activity of aorta phospholipids exceeded that in normal rats. The conclusion is drawn that the rise of the aortic phospholipids specific activity does not derive from increased blood phospholipid concentration but is due to an increased rate of phospholipids synthesis in the aorta tissue.
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This investigation has been done under the Polish-American agreement No 05-008-2 with the Occupational Health Program, U.S. Public Health Service.
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Wrońska-Nofer, T. Aortic phospholipids synthesis in experimental carbon disulphide intoxication in rats. Int. Arch Occup Environ Heath 36, 229–234 (1976). https://doi.org/10.1007/BF00378277
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DOI: https://doi.org/10.1007/BF00378277