Abstract
Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that it can be concluded that astemizole has no potential to induce chromosomal aberrations.
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Ames BN, McCann J, Yamasaki E (1975) Methods for detecting carcinogens and mutagens with Salmonella/mammalian-microsome mutagenicity test. Mutat Res 31: 347–364
Bateman AJ, Epstein SS (1971) Dominant lethal mutations in mammals. In: Hollaender A (ed) Chemical mutagens, vol 2. Plenum Press, New York, p 541
Bateman AJ (1972) The dominant lethal assay in the mouse, International Workshop on Mutagenicity Testing of Drugs and other Chemicals. Workshop Manual (Zurich) 7–14
Brittinger D (1966) Die mutagene Wirkung von Endoxan bei der Maus. Humangenetik 3: 156–165
Fabry L, Roberfroid M (1981) Mutagenicity of aflatoxin B1: Observations in vivo and their relation to in vitro activation. Toxicol Lett 7: 245–250
Generoso WM (1969) Chemical induction of dominant lethals in female mice. Genetics 61: 461–470
Goetz P, Sram RJ, Dolnalova J (1975) Relationship between experimental results in mammals and man. I Cytogenetic analysis of bone marrow injury induced by a single dose of cyclophosphamide. Mutat Res 31: 247–254
Ham RG (1963) An improved nutrient solution for diploid Chinese hamster and human cell lines. Exp Cell Res 29: 515–526
Machemer L, Lorke D (1975) Experiences with the dominant lethal test in female mice: effects of alkylating agents and artificial sweeteners on pre-ovulatory stages. Mutat Res 29: 209–214
Michiels M, Hendriks R, Heykants J (1979) Autoradiographic study of the distribution of R 43512 after intravenous and oral administration to the male Wistar rat. A preliminary experiment. Janssen Pharmaceutica, Preclinical Research Report, R 43512/7
Niemegeers CJE, Awouters F (1979) R 43512: a new, very potent long-acting and specific H1-histamine antagonist, devoid of central activity. Janssen Pharmaceutica, Preclinical Research Report, R 43512
Perry P, Wolff S (1974) New Giemsa method for the differential staining of sister chromatids. Nature 251: 156–158
Poncelet F, Brams A (1981) In vitro mutagenicity study of astemizole. A bacterial study conducted at the laboratory of toxicology and bromatology (U.C.L.). Janssen Pharmaceutica
Röhrborn G (1970) The activity of alkylating agents. I Sensitive mutable stages in spermatogenesis and oogenesis. In: Vogel F, Röhrborn G (eds) Springer, Berlin Heidelberg New York, p 294
Schmid W (1976) The micronucleus test for cytogenetic analysis. In: Hollaender A (ed) Chemical Mutagens, vol 4. Plenum Press, New York, p 31
Seiler JP, Limacher H (1973) The mutagenicity of benzimidazole and benzimidazole derivatives. III The influence of the 2-substituent in benzimidazole on the mutagenic activity. Chimia 27 Nr. 2: 68–70
Seiler JP (1975) The molecular mechanism of benzimidazole mutagenicity: in vitro studies on transcription and translation. Biochem Gen 13: 635–641
Seiler JP (1976) The mutagenicity of benzimidazole and benzimidazole derivatives. VI Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the chinese hamster. Mutat Res 40: 339–348
Styles JA, Garnez R (1974) Benzimidazolecarbamate methyl esterevaluation of its effects in vivo and in vitro. Mutat Res 26: 177–187
Vanparys Ph, Marsboom R (1982) R 43512: sex-linked recessive lethal test on Drosophila melanogaster. Janssen Pharmaceutica, Toxicological research report No. 1087
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Vanparys, P., Fabry, L., Léonard, A. et al. Mutagenicity tests with astemizole in vitro and in vivo. Arch Toxicol 50, 167–173 (1982). https://doi.org/10.1007/BF00373399
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DOI: https://doi.org/10.1007/BF00373399