Abstract
The acute toxicity of 4-ethyl-1-phospha-2,6,7-trioxabicyclo (2.2.2) octane-1-oxide and 4-ethyl-1-phospha-2,6,7-trioxabicyclo (2.2.2) octane has been determined by different routes of application in various species of animals. The compounds stimulate the activity of the central nervous system and are highly toxic. They showed no toxic cumulative effects. The presence of the bicyclic phosphate ester in the combustion products of specific rigid polyurethane foams is dicussed. The question is raised whether there may be an additional hazard caused by this combustion product in a real fire situation.
Zusammenfassung
Die akute Toxicität von 4-Äthyl-1-phospha-2,6,7-trioxabicyclo-(2,2,2)-octan-1 -oxid und 4-Äthyl-1-phospha-2,6,7-trioxabicyclo-(2,2,2)-octan wurde bei verschiedenen Tierarten mittels verschiedener Applikationsarten bestimmt. Die Verbindungen stimulieren die Aktivität des Zentralnervensystems und sind hoch toxisch. Sie zeigen keine kumulativ-toxischen Wirkungen. Das Vorhandensein des bicyclischen Phosphatesters in den Verbrennungsprodukten von spezifischen Polyurethan-Hartschäumen wird diskutiert. Es wird in Frage gestellt, ob dieses Produkt in einer Brandsituation eine zusätzliche Gefahrenquelle darstellt.
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Kimmerle, G., Eben, A., Gröning, P. et al. Acute toxicity of bicyclic phosphorus esters. Arch Toxicol 35, 149–152 (1976). https://doi.org/10.1007/BF00372769
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DOI: https://doi.org/10.1007/BF00372769
Key words
- Bicyclic phosphorus esters
- 4-Ethyl-1-phospha-2,6,7-trioxabicyclic (2.2.2)-octane-1-oxide
- 4-Ethyl-1-phospha-2,6,7-trioxabicyclo (2.2.2)-octane
- Acute toxicity
- combustion products-polyurethane