Abstract
The turnover rate of striatal dopamine (DA) and the effect of l-dopa treatment was investigated in rats after the daily oral administration of MnCl2 · 4H2O for a period of 30 days. The turnover rate of striatal DA, as determined by the administration of α-methyl-p-tyrosine, increased significantly in manganese-exposed rats. l-Dopa administration resulted in a significant elevation in the levels of DA and its metabolite, homovanillic acid, in manganese-exposed rats, but these neurochemical changes could not be correlated with the concentration of manganese in the striatum. We therefore advise that l-dopa therapy should not be tried in early manganese intoxication, as it may aggravate manic symptoms due to marked increase in brain DA.
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Andén NE, Corrodi H, Dahlström A, Fuxe K, Hökfelt T (1966) Effects of tyrosine hydroxylase inhibition on the amine levels of central monoamine neurones. Life Sci 5: 561–568
Bariletto S, Dollar EL, Leitz F (1975) Effect of amantadine on the rate of dopamine synthesis in rat corpus striatum. J Neurochem 25: 139–142
Bartholini G, Blum JE, Pletscher A (1969) DOPA induced locomotor stimulation after inhibition of extracerebral decarboxylase. J Pharm Pharmacol 21: 297–301
Brodie BB, Costa E, Dlabac A, Neff NH, Smooker HM (1966) Application of steady state kinetics to the estimation of synthesis rate and turnover time and tissue catecholamines. J Pharmacol Exp Ther 154: 493–498
Broitman ST, Donoso AO (1971) Locomotor activity and regional brain noradrenaline levels in rats treated with prenylamine. Experientia 27: 1308–1309
Chandra SV, Shukla Girja S (1979) Manganese induced behavioral dysfunction and its neurochemical mechanism in growing mice. J Neurochem 33: 1217–1221
Donaldson J, Pierre T, Munnich JL, Barbeau A (1973) Determination of Na+, Mg2+, Cu2+, Zn2+, Mn2+ in rat brain regions. Can J Biochem 51: 87–92
Goodwin FK, Sack RL (1973) Affective disorders: the catecholamine hypothesis revisited. In: Usdin E, Snyder SH (eds) Frontiers in Catecholamine Research. Pergamon Press, Oxford, pp 1157–1164
Hornykiewicz O (1972) Dopamine and extrapyramidal motor function and dysfunction. Res Publ Assoc Res Nerv Ment Dis 50: 390–412
Hyttel J (1977) Levels of HVA and DOPAC in mouse corpus striatum in the supersensitivity phase after neuroleptic treatment. J Neurochem 28: 227–228
McGeer EG, Gibson S, McGeer PL (1967) Some characteristics of brain tyrosine hydroxylase. Can J Biochem 45: 1557–1563
Mena I, Horiuchi JK, Burke K, Cotzias GC (1969) Chronic manganese poisoning. Individual susceptibility and absorption of iron. Neurology 19: 1000–1006
Mustafa SJ, Chandra Satya V (1971) Levels of 5-hydroxytryptamine, dopamine and norepinephrine in whole brain of rabbits in chronic manganese toxicity. J Neurochem 18: 931–933
Neff NH, Barnett RE, Costa E (1969) Selective depletion of caudate nucleus dopamine and norepinephrine during chronic manganese dioxide administration to squirrel, monkeys. Experientia 25: 1140–1141
Sadavongvivad C (1970) Pharmacological significance of biogenic amines in the lungs: 5-hydroxytryptamine. Br J Pharmacol 38: 353–365
Shukla GS, Dubey MP, Chandra SV (1980) Manganese induced biochemical changes in growing versus adult rats. Arch Environ Contam Toxicol 9: 383–391
Spector S, Sjoerdsma A, Udenfriend S (1965) Blockade of endogenous norepinephrine synthesis by α-methyl-tyrosine, an inhibitor of tyrosine hydroxylase. J Pharmacol Exp Ther 147: 86–95
Thomson ABR, Otatunbosun D, Valberg LS (1971) Interrelation of intenstinal transport system for manganese and iron. J Lab Clin Med 78: 642–655
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Shukla, G.S., Chandra, S.V. Striatal dopamine turnover and l-dopa treatment after short-term exposure of rats to manganese. Arch Toxicol 47, 191–196 (1981). https://doi.org/10.1007/BF00368679
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DOI: https://doi.org/10.1007/BF00368679