Summary
The excretion of the p-nitre-m-cresol was studied after an oral and intraperitoneal administration of Metathion to albino rats. In average 62% and 66% of the theoretical amount of p-nitre-m-cresol were excreted in 7 days respectively. Almost the whole amount of p-nitre-mcresol was excreted three days after administering Metathion.
There is a linear relationship between excreted amount of PNMC and the dose of Metathion.
The experimental results show that p-nitre-m-cresol can be determined in the urine of animals even after small doses of Metathion, which practically do not anymore affect cholinesterase activity in rats.
The presence of p-nitre-m-cresol in urine sensitively points to Metathion exposure.
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Hladká, A., Nosál', M. The determination of the exposition to metathion (Fenitrotion) on the basis of excreting its metabolite p-nitro-m-cresol through urine in rats. Int. Archiv für Gewerbepathologie und Gewerbehygiene 23, 209–214 (1967). https://doi.org/10.1007/BF00368120
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DOI: https://doi.org/10.1007/BF00368120