Abstract
Thallium intoxication in a 28-year-old woman was characterized by neurological and gastrointestinal symptoms and alopecia. Treatment was started 4 days after poisoning and consisted of forced diuresis and administration of Prussian Blue at four daily doses of 5 g by duodenal tube for 20 days. Thallium was measured by atomic absorption spectrophotometry in urine, faeces and saliva. Considerable amounts of thallium were detected in saliva, salivary concentrations being up to 15 times higher than urinary ones. Evidence was also obtained that only a little fraction of the ingested dose was excreted by the intestine during the hospital course in spite of Prussian Blue administration.
References
Cavanagh, J. B., Fuller, N. H., Johnson, H. R. M., Rudge, P.: The effects of thallium salts, with particular reference to the nervous system changes. Q. J. Med. 43, 293–319 (1974)
Curry, A. S., Read, J. F., Knott, A. R.: Determination of thallium in biological material by flame spectrophotometry and atomic absorption. Analyst 94, 744–753 (1969)
Di Nucci, A., Ferrini, B., Gregotti, C., Richelmi, P., Manzo, L.: Placental transfer of thallium and its modification by Prussian Blue. IRCS Med. Sci. 7, 272 (1979)
Drasch, G., Hauck, G.: Verlaufskontrolle der Intensiv-Therapie von Thalliumintoxikationen. Arch. Toxicol. 38, 209–215 (1977)
Gehring, P. J., Hammond, P. B.: The interrelationship between thallium and potassium in animals. J. Pharmacol. Exp. Ther. 155, 187–201 (1967)
Henning, H., Forth, W.: Secretion of thallous ions from the blood into the gastro-intestinal tract in rats. Naunyn-Schmiedebergs Arch. Pharmacol. 302 (Suppl.), R1 (1978)
Heydlauf, H.: Ferric-cyanoferrate (II): an effective antidote in thallium poisoning. Eur. J. Pharmacol. 6, 340–344 (1969)
Hugues, M. M., Man, W. K., Whaler, B. C.: The toxicity of thallium (I) to cardiac and skeletal muscle. Chem. Biol. Interact. 23, 85–97 (1978)
Kamerbeek, H. H., Rauws, A. G., ten Ham, M., van Heijst, A. N. P.: Prussian Blue in therapy of thalliotoxicosis. Acta Med. Scand. 189, 321–324 (1971)
Koch, R., Winter, R., Tüllmann, P., Wiessmann, B.: Forcierte Diurèse bei Thalliumvergiftung. Med. Welt 23, 649–651 (1972)
Lameijer, W., van Zwieten, P. A.: Kinetic behavior of thallium in the rat. Arch. Toxicol. 37, 265–273 (1977)
Lund, A.: Distribution of thallium in the organism and its elimination. Acta Pharmacol. Toxicol. (Kbh.) 12, 251–259 (1956)
Manninen, V., Mälkönen, M., Skulskii, I. A.: Elimination of thallium in rats as influenced by Prussian Blue and sodium chloride. Acta Pharmacol. Toxicol. (Kbh.) 39, 256–261 (1976)
Oehme, F. W.: Mechanisms of heavy metal toxicities. Clin. Toxicol. 5, 151–167 (1972)
Rauws, A. G.: Thallium pharmacokinetics and its modification by Prussian Blue. Naunyn-Schmiedebergs Arch. Pharmacol. 284, 295–306 (1974)
Skulskii, I. A., Manninen, V., Järnefelt, J.: Interaction of thallous ions with the cation transport mechanism in erythrocytes. Biochim. Biophys. Acta 298, 702–709 (1973)
Stevens, W. X., van Peteghem, C., Heyndricks, A., Barbier, F.: Eleven cases of thallium intoxication treated with Prussian Blue. Int. J. Clin. Pharmacol. Biopharm. 10, 1–22 (1974)
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Richelmi, P., Bono, F., Guardia, L. et al. Salivary levels of thallium in acute human poisoning. Arch. Toxicol. 43, 321–325 (1980). https://doi.org/10.1007/BF00366188
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DOI: https://doi.org/10.1007/BF00366188