Abstract
The small bristles (microchaetes) on the thorax of adult Drosophila are evenly spaced. We have analysed the development of this pattern using the enhancer trap line A101 where bacterial lacZ is expressed in the microchaete sensory mother cells (SMCs) and their progeny. We observed that the precursor cells appear in a stereotyped pattern of rows. Within each row, however, SMCs appear neither at a time nor in a restricted sequence: new SMCs are continuously intercalated between pre-existing SMCs until the distance between consecutive SMCs does not exceed a few cell diameters. In large individuals, additional SMCs may occasionally appear after the completion of the rows, in the largest empty spaces between the preexisting SMCs.
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References
Bate CM (1978) Development of sensory systems in arthropods. In: Jacobson M (ed) Handbook of sensory physiology. Springer, Berlin Heidelberg New York, pp 1–53
Bellen HJ, O'Kane CJ, Wilson C, Grossniklaus U, Pearson RK, Gehring WJ (1989) P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev 3:1288–1300
Boulianne GL, Delaconcha A, Campos-Ortega JA, Jan LY, Jan YN (1991) The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J 10:2975–2983
Bryant PJ (1978) Pattern formation in imaginal discs. In: Ashburner M, Wright TRF (eds) The genetics and biology of Drosophila 2c. Academic Press, London, pp 230–325
Celis JF de, Marí-Beffa M, García-Bellido A (1991) Function of trans-acting genes of the achaete-scute complex in sensory organ patterning in the mesonotum of Drosophila. Roux's Arch Dev Biol 200:64–76
Claxton JH (1964) The determination of patterns with special reference to that of the central primary skin follicles in sheep. J Theor Biol 7:302–317
Claxton JH (1976) Developmental origin of even spacing between the microchaetes of Drosophila melanogaster. Aust J Biol Sci 29:131–135
Cubas P, Celis JF de, Campuzano S, Modolell J (1991) Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev 5:996–1008
García-Bellido A (1979) Genetic analysis of the achaete-scute system of Drosophila melanogaster. Genetics 91:491–520
Ghysen A, Dambly-Chaudière C (1988) From DNA to form: the achaete-scute complex. Genes Dev 2:497–501
Ghysen A, Dambly-Chaudière C (1989) Genesis of the Drosophila peripheral nervous system. Trends Genet 5:251–255
Hartenstein V, Posakony JW (1989) Development of adult sensilla on the wing and notum of Drosophila. Development 107:389–405
Hartenstein V, Posakony JW (1990) A dual function of the Notch gene in Drosophila sensillum development. Dev Biol 142:13–30
Held LI Jr (1990) Sensitive periods for abnormal patterning on a leg segment in Drosophila melanogaster. Roux's Archive Dev Biol 199:31–47
Held LI Jr (1991) Bristle patterning in Drosophila. BioEssays 13:633–640
Huang F, Dambly-Chaudière C, Ghysen A (1991) The emergence of sense organs in the wing disc of Drosophila. Development 111:1087–1095
Jan YN, Jan LY (1990) Genes required for specifying cell fates in Drosophila embryonic sensory nervous system. Trends Neurosci 13:493–498
Lawrence PA (1969) Cellular differentiation and pattern formation during metamorphosis of the milkweed bug Oncopeltus. Dev Biol 19:12–40
Lawrence PA (1992) The making of a fly. Blackwell Scientific Publications, London
Lawrence PA, Hayward P (1971) The development of a simple pattern: spaced hairs in Oncopeltus fasciatus. J Cell Sci 8:513–524
Mlodzik M, Baker NE, Rubin GM (1990) Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Genes Dev 4:1848–1861
Moscoso del Prado J, García-Bellido A (1984a) Genetic regulation of the achaete-scute complex of Drosophila melanogaster. Roux's Arch Dev Biol 193:242–245
Moscoso del Prado J, García-Bellido A (1984b) Cell interactions in the generation of chaete pattern in Drosophila. Roux's Arch Dev Biol 193:246–251
Poodry CA (1975) A temporal pattern in the development of sensory bristles in Drosophila. Wilhelm Roux's Arch Entwicklungsmech 178:203–213
Rodriguez I, Hernández R, Modolell J, Ruiz-Gómez M (1990) Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primodia. EMBO J 9:3583–3592
Romani S, Campuzano S, Macagno ER, Modolell J (1989) Expression of achaete and scute genes in Drosophila imaginal discs and their function in sensory organ development. Genes Dev 3:997–1007
Ruiz-Gómez M, Modolell J (1987) Deletion analysis of the achaete-scute locus of Drosophila melanogaster. Genes Dev 1:1238–1246
Simpson P (1990a) Notch and the choice of cell fate in Drosophila neuroepithelium. Trends Genet 6:343–345
Simpson P (1990b) Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. Development 109:509–519
Skeath JB, Carroll SB (1991) Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev 5:984–995
Turing AM (1952) The chemical basis of morphogenesis. Phil Trans R Soc London Ser B 237:37–72
Wigglesworth VB (1940) Local and general factors in the development of “pattern” in Rhodnius prolixus. J Exp Biol 17:180–200
Wilson C, Pearson RK, Bellen HJ, O'Kane CJ, Grossniklaus U, Gehring WJ (1989) P-element-mediated enhancer detection: and efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev 3:1301–1313
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Correspondence to: K. Kimura
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Usui, K., Kimura, Ki. Sequential emergence of the evenly spaced microchaetes on the notum of Drosophila . Roux's Arch Dev Biol 203, 151–158 (1993). https://doi.org/10.1007/BF00365054
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DOI: https://doi.org/10.1007/BF00365054