Abstract
The accumulation of intravascular fibrin thrombosis in both acute and chronic renal rejection leads to a delay in the transit of perfusion. This study examines the renal washout parameter as an indicator of transit time. By mathematical simulation of renal time-activity curves various factors which can influence this parameter are investigated, a simple analysis is proposed and clinical results are correlated with biopsy findings. A washout parameter greater than 28 s is found to be consistent with histologically diagnosed rejection over a range of bolus qualities.
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References
Canavan JSF, Baillie AG, Briggs JD, Horton PW, Minchin PEH (1977) Technetium scanning of renal allografts. Clin Nephrol 8:440–445
Dunagin P, Alijani M, Atkins F, Favila M, Light J (1983) Application of the kidney to aortic blood flow index to renal transplants. Clin Nucl Med 8:360–364
George EA (1982) Radionuclide diagnosis of Allograft Rejection. Sem Nucl Med 12:379–386
Howard RJ, Sutherland DER, Naja Rian JS (1973) Detection of renal allograft rejection with 125-I fibrinogen. J Surg Res 15:251–254
Kirchner PT, Rosenthall L (1982) Renal Transplant Evaluation. Semin Nucl Med 12:370–378
Leonard JC, Baumann WE, Pederson JA, roy JB (1980) 99m-Technetium Sulfur Colloid scanning in the diangosis of renal transplant rejection. J Urol 123:815–818
Peterdy AE, Sutherland JB, Jeffery J, Benediktsson H, Greenberg JD (1981) Renal Transplant uptake of Technetium-99m Sulfur Colloid in various time periods after transplantation. J Can Ass Radiologists 32:144–148
Preston DF, Luke RG (1979) Radionuclide evaluation of renal transplants. J Nucl Med 20:1095–1097
Quinlan JA, Dagher FJ, Loberg MD, Olladart RM, Frost JL, Mason GR, Cooper MD (1975) Early detection of acute rejection in renal allografts using radioionated autologus fibrinogen. Am J Surg 130:136–142
Reeve J, Crawley JCW (1974) Quantitative radioisotope renography: the derivation of physiological data by deconvolution analysis using a single injection technique. Clin Sci Mol Med 47:317–330
Thompson HK, Starmer FC, Whalen RE, McIntosh HD (1964) Indicator transit time considered as a gamma variate. Circ Res 14:502–515
Valentinuzzi ME, Montalado-Volachec EM (1975) Discrete deconvolution. Med Biol Eng Comput 13:123–125
Zierler KL (1965) Equations for measuring blood flow by external monitoring of radioisotopes. Circ Res 16:309–321
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Jackson, S.A., Ehrlich, L. & Martin, R.H. The renal washout parameter as an indicator of transplant rejection. Eur J Nucl Med 12, 86–90 (1986). https://doi.org/10.1007/BF00364735
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DOI: https://doi.org/10.1007/BF00364735