Abstract
A total of 131 patients with old (over 6 months) myocardial infarction (MI) and 18 normal subjects underwent equilibrium radionuclide angiocardiography at rest (rERNA). The following rERNA parameters were assessed: left ventricular ejection fraction (LVEF), peak ejection rate (PER), peak filling rate (PFR), regional wall motion and a left ventricular size index. The patients with old MI were divided into four groups (I to IV) according to increasing left ventricular (LV) size, and the behaviour of the numerical parameters (LVEF, PER, PFR) was evaluated in each group. LVEF proved to be the most sensitive numerical parameter of overall LV performance. PFR decreased significantly from group I to group III but not from group III to group IV, suggesting that for extreme degrees of left ventricular enlargement some compensatory mechanism acts to prevent a too large fall in LV compliance. The effects of the site of the previous MI on LV performance were also evaluated. Both LV size and performance were least affected by postero-inferior MI. The LVEF was, however, a better predictor of LV size than the site of the MI.
Similar content being viewed by others
References
Adam WR, Tarkowska A, Bitter F, Stauch M, Geffers H (1979) Equilibrium (gated) radionuclide ventriculography. Cardiovasc Intervent Radiol 2:161–173
Bonow RO, Bacharach SL, Green MV, Kent KM, Rosing DR, Lipson LC, Leon MB, Epstein SE (1981) Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography. Circulation 64:315–323
Covell JW, Ross J (1973) Nature and significance of alterations in myocardial complicance. Am J Cardiol 32:449–455
Gaasch WH, Levine HJ, Quinones MA, Alexander JK (1976) Left ventricular complicance: mechanisms and clinical implications. Am J Cardiol 38:645–653
Kitamura S, Kay JH, Krohn BG, Magidson O, Dunne EF (1973) Geometric and functional abnormalities of the left ventricle with a chronic localized noncontractile area. Am J Cardiol 31:701–707
Maini CL, Galli G, Bonetti MG, Manna R (1984) Multiple gated nuclear angiography performed at rest to evaluate left ventricular function in clinically asymptomatic diabetic patients. Nucl Med Commun 5:681–688
Maini CL, Antonelli Incalzi R, Bonetti MG, Valle G, Montenero AS (1985) Left ventricular diastolic performance at rest in patients with angina and a normal systolic function. Assessment by equilibrium radionuclide angiography. Nuklearmedizin 24:159–163
Mann T, Goldberg S, Mudge GH, Grossman W (1979) Factors contributing to altered left ventricular diastolic properties during angina pectoris. Circulation 59:14–20
Marmor A,Geltman EM, Biello DR, Sobel BE, Siegel BA, Roberts R (1981) Functional response of the right ventricle to myocardial infarction: dependence on the site of left ventricular infarction. Circulation 64:1005–1011
Miller TR, Goldman KJ, Sampathkumaran KS, Biello DR, Ludbrook PA, Sobel BE (1983) Analysis of cardiac diastolic function: application in coronary artery disese. J Nucl Med 24:2–7
Newell JD, Higgins CB, Kelley MJ (1980) Radiographic-echocardiographic approach to acquired heart disease: diagnosis and assessment of severity. Radiol Clin North Am 18:387–409
Polak JF, Kemper AJ, Bianco JA, Parisi AF, Tow DE (1982) Resting early peak diastolic filling rate: a sensitive index of myocardial dysfunction in patients with coronary artery disease. J Nucl Med 23:471–478
Reduto LA, Wickemeyer WJ, Young JB, Del Ventura LA, Reid JW, Glaeser DH, Quinones MA, Miller RR (1981) Left ventricular diastolic performance at rest and during exercise in patients with coronary artery disease. Circulation 61:1228–1237
Smith M, Russel RO, Feild BJ, Rackly CE (1974) Left ventricular compliance and abnormally contracting segments in postmyocardial infarction patients. Chest 65:368–371
Tebbe U, Hoffmeister N, Saur G, Newhouse KL, Kreuzer H (1980) Changes in left ventricular diastolic function in coronary artery disease with and without angina pectoris assessed from exercise ventriculography. Clin Cardiol 3:19–24
Author information
Authors and Affiliations
Additional information
Supported in part by grant no. 71260 by Ministero della Publica Istruzione
Rights and permissions
About this article
Cite this article
Maini, C.L., Incalzi, R.A., Bonetti, M.G. et al. Correlation of functional parameters derived by equilibrium radionuclide angiocardiography and left ventricular size in patients with old myocardial infarction. Eur J Nucl Med 12, 60–64 (1986). https://doi.org/10.1007/BF00364729
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00364729