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Skin graft rejection and delayed-type hypersensitivity responses to H-Y in an I-A b mutant

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Abstract

Based on graft rejection in C57BL/6 and B10.A(4R), but not in B10.A mice, skin graft rejection and delayed-type hypersensitivity (DTH) responses to the male HY antigen were considered to be under the control of the “IBb” gene in the mouse H-2 complex. These two phenomena were re-examined in the B6.C-H-2bm12 mutant strain [mutation in the A βgene in IA leading to an alteration in Iab serologically detected specificities and the inability to generate cytotoxic T (Tc) cells to H-Y]. In this study the bm12 mutant was shown to produce weak DTH responses to H-Y. By contrast, bm12 female mice were unable to reject male skin grafts unless they had received prior footpad priming of male spleen cells, when graft rejection occurred, albeit slowly. In C57BL/6 mice the response to the HY antigen therefore appears to be solely under the control of the IA b gene. In other strains, response/nonresponse is presumably dictated by the ability of IA/IE interactions to produce T-helper responses.

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Authors and Affiliations

  1. Research Centre for Cancer and Transplantation, Department of Pathology, The University of Melbourne, 3052, Parkville, Victoria, Australia

    I. F. C. McKenzie, M. M. Henning & M. Michaelides

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  1. I. F. C. McKenzie
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  2. M. M. Henning
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  3. M. Michaelides
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McKenzie, I.F.C., Henning, M.M. & Michaelides, M. Skin graft rejection and delayed-type hypersensitivity responses to H-Y in an I-A b mutant. Immunogenetics 20, 475–480 (1984). https://doi.org/10.1007/BF00364350

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  • DOI: https://doi.org/10.1007/BF00364350

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