Abstract
Liver tissue grafts between seven H-2 mutants and their parental strains have been studied. Each of these mutants was originally identified by reciprocal mutant—parental strain skin graft rejection. However, liver grafts among mutants and parental standard strains are not uniformly rejected. Liver graft rejection also fails to correlate with mutant—parental stimulation in CML and MLC. In addition, the immune reaction pattern of female mutant animals against grafts of male liver differs from the reaction pattern found in parental standard strains. Several explanations for the differences between immune response to liver and skin grafts are proposed, including different T cell subsets involved in recognition, availability of antigenic sites to immunocompetent cells, and structural differences between mutant and parental H-2 antigens.
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Apt, A. S., Blandova, Z. K., Dishkant, I. P., Shumova, T. E., Vedernikov, A. A., and Egorov, I. K.: Study of H-2 mutations in mice: IV. A comparison of the mutants M505 and Hz1 by skin grafting and serological techniques. Immunogenetics 1: 444–451, 1975
Bailey, D. W. and Usama, B.: A rapid method of skin grafting on tails of mice. Transplant. Bull. 7: 424–425, 1960
Ben-Nun, A., Maron, R., Ron, Y., and Cohen, I. R.: H-2 gene products influence susceptibility of target thyroid gland to damage in experimental autoimmune thyroiditis. Eur. J. Immunol. 10: 156–159, 1980
Bennett, M., Melvold, R. W., and Kohn, H. I.: Bone-marrow-cell grafts involving the H-2D and H-2L mutant haplotypes. Immunogenetics 10: 273–281, 1980
Brown, J. L. and Nathenson, S.: Structural differences between parent and mutant H-2K glycoproteins from two H-2K gene mutants: B6.C-H-2 ba (Hz1) and B6-H-2 bd(M505). J. Imnunol. 118: 98–102, 1977
Brown, J. L., Nairn, R., and Nathenson, S. G.: Structural differences between the mouse H-2D products of the mutant B10.D2.M504 (H-2da and the parental nonmutant strain B1 0.D2 (H-2d). J. Immunol. 120: 726–733, 1978
Davis, W. C., McKenzie, I. F. C., and Melvold, R. W.: A comparison of skin and heart graft reaction patterns in H-2 mutant mice. Transplantation 29: 189–192, 1980
DeMott-Friberg, R., Beals, T. F., and Schultz, J. S.: H-2 and background influences on tissue grafts across the H-Y barrier. Immunogenetics 9: 369–381, 1979
Egorov, I. K.: Genetic control of H-2 alloantigen as inferred from analysis of mutations. Immunogenetics 1: 97–107, 1974
Egorov, I. K., Pospelov, L. E. Shkurko, V. N., Mnatsakanyan, Y. A., and Khodjaen, E. Y.: Study of H-2 mutations in mice. VIII. Aberrant expression of H-2.5 Antigen on Red Blood Cells of H-2 6 mutants. Immunogenetics 8: 161–170, 1979
Ewenstein, B. M., Uehara, H., Nisizawa, T., Melvold, R. W., Kohn, H. I., and Nathenson, S. G.: Biochemical studies on the H-2K antigens of the MHC mutants bm3 and bm11. Immunogenetics 11: 388–395, 1980
Klein, J., Chiang, C. L., Lofgreen, J., and Steinmuller, D.: Participation of H-2 regions in heart-transplant rejection. Transplantation 22: 384–390, 1976
Klein, J.: H-2 Mutations: Their genetics and effect on immune functions. Adv. Immunol. 26: 56–146, 1978
Kohn, H. I., Klein, J., Melvold, R. W., Nathenson, S. G., Pious, D., and Shreffler, D. C.: The first H-2 mutant workshop. Immunogenetics 7: 279–294, 1978
McKenzie, I. F. C., Morgan, G. M., Sandrin, M. S., Michaelides, M. M., Melvold, R. W., and Kohn, H. I.: B6.C-H-2 bm12 A new H-2 mutation in the I region in the mouse. J. Exp. Med. 150: 1323–1338, 1979
Melief, C. J. M., de Waal, L. P., van der Meulen, M. Y., Melvold, R. W., and Kohn, H. I.: Fine specificity of alloimmune cytotoxic T lymphocytes directed against H-2K. J. Exp. Med. 151: 993–1013, 1980
Nairn, R., Yamaga, K., and Nathenson, S. G.: Biochemistry of the gene products from murine MHC mutants. Annu. Rev. Genet. 14: 241–277, 1980
Nisizawa, T., Ewenstein, B. M., Uehara, H., McGovern, D., and Nathenson, S. G.: Biochemical Studies on the H-2K antigens of the MHC mutant bm1. Immunogenetics 12: 33–44, 1981
Schultz, J. S., Beals, T. F., and Petraitis, F. P.: Tissue graft rejection in mice. I. Contributions of H-2 and non-H-2 genetic barriers. Immunogeneties 3: 85–96, 1976
Schultz, J. S., Beals, T. F., and DeMott-Friberg, R.: Tissue graft rejection in mice. V. Survival, rejection, or proliferation across minor barriers. Immunogenetics 6: 585–595, 1978
Schultz, J. S., DeMott-Friberg, R., and Beals, T. F.: Immunogenetic control of the response of female mice to male tissue grafts. Immunogenetics 12: 199–205, 1981
Streilein, J. W. and Klein, J.: Neonatal tolerance induction across H-2 mutational disparity: Induction and specificity of tolerance: Immunogenetics 10: 113–123, 1980
Wilson, P. H., Nairn, R., Nathenson, S. G., and Sears, D. W.: Unexpected complexity of the dml mutation revealed in the structures of three H-2D/L-related antigens: Immunogenetics 15: 225–237, 1982
Wu, S., Bach, F. H., and Sopori, M.: Differential alloresponse of murine thymocytes to H-2K b region different recombinants and to H-2Kb mutants: J. Immunol. 124: 2464–2467, 1980
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Abbreviations used in this paper: bml, 2, 3, 4,14; dml; fm2=mutants of strains C57BL/6, B10.D2 and B10.M respectively; B6=C57BL/6
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Schultz, J.S., DeMott-Friberg, R. & Beals, T.F. Liver tissue graft rejection in murine major histocompatibility complex mutants. Immunogenetics 15, 357–364 (1982). https://doi.org/10.1007/BF00364259
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DOI: https://doi.org/10.1007/BF00364259