Skip to main content
SpringerLink
Log in

Mismatch recognition in chromosomal interactions and speciation

  • Chromosoma Focus
  • Published:
Chromosoma Aims and scope Submit manuscript

Abstract

Homologous chromosomes interact during meiosis by means of proteins involved in recombination and in the recognition and repair of mismatched base pairs. Recombination proteins bring homologous chromosomes or chromosomal regions together by facilitating the search for DNA homology and by catalyzing strand exchange between homologous molecules or regions. Mismatch recognition and repair proteins act as editors of recombination and appear to disrupt those DNA associations that contain mismatched base pairs. Thus, it may be that, as chromosomes diverge in their primary sequence and become increasingly polymorphic, recombinational interactions leading to chromosome pairing and recombination tend to be inhibited. Decreasing homologous interactions within and between chromosomes will clearly contribute to maintaing the integrity of individual chromosomes and may utimately lead, as a result of sterile meioses, to the reproductive isolation of closely related species.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bianchi M, Radding CM (1983) Insertions, deletions and mismatches in heteroduplex DNA made by recA protein. Cell 35:511–520

    Google Scholar 

  • Bollag RJ, Waldman AS, Liskay RM (1989) Homologous recombination in mammalian cells. Annu Rev Genet 23:199–225

    Google Scholar 

  • Carpenter ATC (1987) Gene conversion recombination nodules and the initiation of meiotic synopsis. BioEssays 6:232–236

    Google Scholar 

  • Claverys JP, Lacks SA (1986) Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria. Microbiol Rev 50:133–165

    Google Scholar 

  • Damagnez V, Doutriaux MP, Radman M (1989) Saturation of mismatch repair in the muntD5 mutator strain of Escherichia coli. J Bacteriol 171:4494–4497

    Google Scholar 

  • Dorit RL, Schoenbach L, Gilbert W (1990) How big is the universe of exons? Science 250:1377–1382

    Google Scholar 

  • Feinstein SI, Low KB (1986) Hyper-recombining recipients strains in bacterial conjugation. Genetics 113:13–33

    Google Scholar 

  • Fujii H, Shimada T (1989) Isolation and characterization of cDNA clones derived from divergently transcribed gene in the region upstream from human dihydrofolate reductase gene. J Biol Chem 264:10057–10064

    Google Scholar 

  • Goldway M, Sherman A, Zenvirth D, Arbel T, Simchen G (1993) A short chromosomal region with major in yeast chromosome III meiotic disjunction, recombination and double strand break. Genetics 133:159–169

    Google Scholar 

  • Haber JE, Leung WY, Borts RH, Lichten M (1991) “The frequency meiotic recombination in yeast is independent of the number and position of homologous donor sequences: implications for chromosome pairing”. Proc Natl Acad Sci USA 88:1120–1124

    Google Scholar 

  • Hawley RS (1988) Exchange and chromosomal segregation in Eucaryotes. In: Kucherlapati R, Smith GR (eds) Genetic recombination, pp 497–527. American Society for Microbiology Washington, DC

    Google Scholar 

  • Hawley RS, Arbel T (1993) Yeast genetics and the fall of the classical view of meiosis. Cell 72:301–303

    Google Scholar 

  • Holliday R (1964) A mechanism for gene conversion in fungi. Genet Res 5:282–304

    Google Scholar 

  • Hotta Y, Tabata S, Stern H (1984) Replication and nicking of zygotene DNA sequences. Control by a meiosis-specific protein. Chromosoma 90:243–253

    Google Scholar 

  • Hsich P, Camerini-Otero C, Camerini-Otero D (1992) The synapsis event in the homologous pairing of DNAs: RecA recognizes and pairs less than one helical repeat of DNA. Proc Natl Acad Sci USA 89:6492–6496

    Google Scholar 

  • Jones M, Wagner R, Radman M (1987) Mismatch repair and recombination in E. coli. Cell 50:621–626

    Google Scholar 

  • Jorgensen R (1990) Altered gene expression in plants due to trans interactions between homologous genes. Trends Biotech 8:340–344

    Google Scholar 

  • Kleckner N, Padmore R, Bishop DK (1991) Meiotic chromosome metabolism: one view. Cold Spring Harbor Symp Quant Biol 56:729–743

    Google Scholar 

  • Kramer W, Kramer M, Williamson S, Fogel S (1989) Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology to procaryotic MutL and HexB. J Bacteriol 171:5339–5346

    Google Scholar 

  • Kricker MC, Drake JW, Radman M (1992) Duplication-targeted DNA methylation and mutagenesis in the evolution of eucaryotic chromosomes. Proc Natl Acad Sci USA 89:1075–1079

    Google Scholar 

  • Lichten M, Goyon C, Schultes NP, Tieco D, Szostak JW, Haber JE, Nicolas A (1990) Detection of heteroduplex. DNA molecules among the products of Saccharomyces cerevisiae meiosis. Proc Natl Acad Sci USA 87:7653–7657

    Google Scholar 

  • Lichten M, Fox M (1984) Evidence for inclusion of regions of non-homology in heteroduplex products of bacteriophage lambda recombination. Proc Natl Acad Sci USA 81:7180–7184

    Google Scholar 

  • Lundblad V, Kleckner N (1984) Mismatch repair mutations in E. coli enhance transposon excision. Genetics 109:3–19

    Google Scholar 

  • Jinks-Robertson S, Michelitch M (1993) Substrate length requirement for efficient mitotic recombination in yeast; Mol Cell Biol (in press)

  • Miret JJ, Milla MG, Lahue RS (1993) Characterisation of a DNA mismatch-binding activity in yeast extracts. J Biol Chem 268:3507–3513

    Google Scholar 

  • Modrich P (1991) Mechanisms and biological effects of mismatch repair. Annu Rev Genet 25:229–253

    Google Scholar 

  • New L, Liu K, Crouse GF (1993) The yeast gene MSH3 defines a new class of eukaryotic MutS homologs. Mol Gen Genet (in press)

  • Ochman H, Wilson AC (1987) Evolution in bacteria: evidence for a universal rate in cellular genomes. J Mol Evol 26:74–86

    Google Scholar 

  • Petes TD, Hill CW (1988) Recombination between repeated genes in microorganisms. Annu Rev Genet 22:147–168

    Google Scholar 

  • Petit MA, Dimpfl J, Radman M, Echols H (1991) Control of chromosomal rearrangements in E. coli by the mismatch repair system. Genetics 129:327–332

    Google Scholar 

  • Radman M (1988) Mismatch repair and genetic recombination. In: Kucherlapati R, Smith GR (eds), Genetic recombination, pp 169–192 American Society for Microbiology, Washington, DC

    Google Scholar 

  • Radman M (1989) Mismatch repair and the fidelity of genetic recombination. Genome 31:68–73

    Google Scholar 

  • Radman M (1991) Avoidance of inter-repeat recombination by sequence divergence and a mechanism of neutral evolution. Biochimie 73:357–361

    Google Scholar 

  • Radman M, Wagner R (1986) Mismatch repair in Escherichia coli. Annu Rev Genet 20:523–538

    Google Scholar 

  • Rassoulzadegan M, Cuzin F, Radman M (1990) Progressive extinction and methylation of transgenes in the somatic tissues of transgenic mice. In: Abstract book of the Cold Spring Harbor meeting on mouse genetics, p 70

  • Rayssiguier C, Thaler DS, Radman M (1989) The barrier to recombination between Escherichia coli and Salmonella typhirium is disrupted in mismatch-repair mutants. Nature 342:396–401

    Google Scholar 

  • Reenan RAG, Kolodner RD (1992a) Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics 132:963–973

    Google Scholar 

  • Reenan RAG, Kolodner RD (1992b) Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics 132:975–985

    Google Scholar 

  • Resnick MA, Skaanild M, Nilsson-Tilgren T (1989) Lack of DNA homology DNA damage. Proc Natl Acad Sci USA 86:2276–2280

    Google Scholar 

  • Rhounim L, Rossignol JL, Faugeron G (1992) Epimutation of repeated genes in Ascolobus immersus. EMBO J 11:4451–4457

    Google Scholar 

  • Roeder GS (1990) Chromosome synapsis and genetic recombination: their roles in meiotic chromosomal segregation. Trends Genet 6:385–389

    Google Scholar 

  • Schaaper RM, Radman M (1989) The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors. EMBO J 8:3511–3516

    Google Scholar 

  • Schultes NP, Szostack JW (1990) Decreasing gradients of gene conversion in both sides of the initiation site for meiotic recombination at the ARGY locus in yeast. Genetics 126:813–822

    Google Scholar 

  • Selker EU (1990) Premeiotic instability of repeated sequences in Neurospora crassa. Annu Rev Genet 24:579–613

    Google Scholar 

  • Shar P, Kohli J (1993) Marker effects of G to C transversions on intragenic recombination and mismatch repair in Schizosaccharomyces pomble. Genetics 133:825–835

    Google Scholar 

  • Shen P, Huang HV (1986) Homologous recombination in Escherichia coli: dependence on substrate length and homology. Genetics 112:441–457

    Google Scholar 

  • Shen P, Huang HV (1989) Effect of base pair mismatches on recombination via RecBCD pathway. Mol Gen Genet 218:358–360

    Google Scholar 

  • Shen JC, Rideout III WM, Jones PA (1992) High frequency mutagenesis by a DNA methyltransferase. Cell 71:1073–1080

    Google Scholar 

  • Te Riele H, Mandaag, Berns A (1992) Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc Natl Acad Sci USA 89:5128–5132

    Google Scholar 

  • Voelker-Meiman K, Roeder SG (1990) Gene conversion tracts stimulated by HOTI-promoted trascription are long and continuous. Genetics 126:851–867

    Google Scholar 

  • West SC (1992) Enzymes and molecular mechanisms of genetic recombination. Annu Rev Biochem 61:603–640

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute Jacques Monod, CNRS-Université Paris 7, 2, Place Jussieu, F-75251, Paris Cedex 05, France

    Miroslav Radman & Robert Wagner

Authors
  1. Miroslav Radman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Radman, M., Wagner, R. Mismatch recognition in chromosomal interactions and speciation. Chromosoma 102, 369–373 (1993). https://doi.org/10.1007/BF00360400

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00360400

Keywords

Search

Navigation