Abstract
The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each.
In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and band neutrophils, was demonstrated.
Cellulose-coated activated charcoal and, to a lesser extent, polystyrene resin induced activation of the complement system using C3d as a parameter.
An appreciable decrease of immunoglobulin or complement levels could not be demonstrated in either column.
Similar content being viewed by others
References
Agar JW, Hull JD, Kaplan M, Pletka PG (1979) Acute cardiopulmonary decompensation and complement activation during hemodialysis. Ann Int Med 90: 792–793
Ajama P, Bird PAE, Ward MK, Feest TG, Walker W, Fanboga H (1978) Haemodialysis-induced leucopenia and activation of complement: effects of different membranes. Proc Eur Dial Transplant Assoc 15: 144–153
Bismuth C, Scherrmann JM (1980) Hémoperfusion sur charbon activé enrobé. Méd Lég Toxicol 23: 23–26
Brookings CH, Ramsey JD (1975) Salicylate removal by charcoal haemoperfusion in experimental intoxications in dogs: an assessment of efficacy and safety. Arch Toxicol 34: 243–252
Chenoweth DE, Hugli TE (1978) Demonstration of specific C5a receptor on intact human polymorphonuclear leucocytes. Proc Natl Acad Sci USA 75: 3943–3947
Chenoweth DE, Cooper SW, Hugli TE, Stewart RW, Blackstone EH, Kirklin JW (1981) Complement activation during cardiopulmonary bypass. N Engl J Med 304: 497–503
Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacobs HS (1977) Hemodialysis leucopenia: pulmonary vascular leucostasis resulting from complement activation by dializer cellophane membranes. J Clin Invest 59: 879–888
Craddock PR, Fehr J, Brigham KL, Kronenberg PJ, Jacobs HS (1977) Complement and leucocyte-mediated pulmonary dysfunction in haemodialysis. N Engl J Med 296: 769–774
Heath A, Delin K, Eden E, Mårtensson E, Selander D, Wickström I, Ahlmen J (1980) Hemoperfusion with Amberlite resin in the treatment of selfpoisoning. Acta Med Scand 207: 455–460
Hennemann H, Richter IE, Brunswig D, Rockel A, Kult J, Gattenlohner W, Heidland A (1977) Hämoperfusion — Pro und Contra. Klin Wochenschr 55: 533–537
Kauffmann RH, Herrmann WA, Meijer CJLM, Daha MR, Es LA van (1980) Circulating IgA-immune-complexer in Henoch-Schönlein purpura. Am J Med 69: 859–866
Kolthammer JC, Watson PA, Lang S, Fennimore J (1976) The safety assessment in the dog of a charcoal haemoperfusion column. Clin Sci Mol Med 51: 515–524
Pall H, Kleinberger G, Kotzaurek R, Niesser H, Pichler M (1977) Gerinungsstörungen im Rahmen der Hämoperfusion. Wien Klin Wochenschr 89: 347–350
Sangster B, Heijst ANP van, Sixma J (1981) The influence of haemoperfusion on haemostasis and cellulose constituents of the blood in the treatment of intoxications. Arch Toxicol 47: 269–278
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rommes, J.H., Sangster, B., Gmelig Meyling, F.H.J. et al. The influence of haemoperfusion on white cells, immunoglobulin concentrations and the complementsystem in the treatment of intoxications. Arch Toxicol 52, 149–156 (1983). https://doi.org/10.1007/BF00354774
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00354774