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The influence of haemoperfusion on white cells, immunoglobulin concentrations and the complementsystem in the treatment of intoxications

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Abstract

The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each.

In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and band neutrophils, was demonstrated.

Cellulose-coated activated charcoal and, to a lesser extent, polystyrene resin induced activation of the complement system using C3d as a parameter.

An appreciable decrease of immunoglobulin or complement levels could not be demonstrated in either column.

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References

  • Agar JW, Hull JD, Kaplan M, Pletka PG (1979) Acute cardiopulmonary decompensation and complement activation during hemodialysis. Ann Int Med 90: 792–793

    Google Scholar 

  • Ajama P, Bird PAE, Ward MK, Feest TG, Walker W, Fanboga H (1978) Haemodialysis-induced leucopenia and activation of complement: effects of different membranes. Proc Eur Dial Transplant Assoc 15: 144–153

    Google Scholar 

  • Bismuth C, Scherrmann JM (1980) Hémoperfusion sur charbon activé enrobé. Méd Lég Toxicol 23: 23–26

    Google Scholar 

  • Brookings CH, Ramsey JD (1975) Salicylate removal by charcoal haemoperfusion in experimental intoxications in dogs: an assessment of efficacy and safety. Arch Toxicol 34: 243–252

    Google Scholar 

  • Chenoweth DE, Hugli TE (1978) Demonstration of specific C5a receptor on intact human polymorphonuclear leucocytes. Proc Natl Acad Sci USA 75: 3943–3947

    Google Scholar 

  • Chenoweth DE, Cooper SW, Hugli TE, Stewart RW, Blackstone EH, Kirklin JW (1981) Complement activation during cardiopulmonary bypass. N Engl J Med 304: 497–503

    Google Scholar 

  • Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacobs HS (1977) Hemodialysis leucopenia: pulmonary vascular leucostasis resulting from complement activation by dializer cellophane membranes. J Clin Invest 59: 879–888

    Google Scholar 

  • Craddock PR, Fehr J, Brigham KL, Kronenberg PJ, Jacobs HS (1977) Complement and leucocyte-mediated pulmonary dysfunction in haemodialysis. N Engl J Med 296: 769–774

    Google Scholar 

  • Heath A, Delin K, Eden E, Mårtensson E, Selander D, Wickström I, Ahlmen J (1980) Hemoperfusion with Amberlite resin in the treatment of selfpoisoning. Acta Med Scand 207: 455–460

    Google Scholar 

  • Hennemann H, Richter IE, Brunswig D, Rockel A, Kult J, Gattenlohner W, Heidland A (1977) Hämoperfusion — Pro und Contra. Klin Wochenschr 55: 533–537

    Google Scholar 

  • Kauffmann RH, Herrmann WA, Meijer CJLM, Daha MR, Es LA van (1980) Circulating IgA-immune-complexer in Henoch-Schönlein purpura. Am J Med 69: 859–866

    Google Scholar 

  • Kolthammer JC, Watson PA, Lang S, Fennimore J (1976) The safety assessment in the dog of a charcoal haemoperfusion column. Clin Sci Mol Med 51: 515–524

    Google Scholar 

  • Pall H, Kleinberger G, Kotzaurek R, Niesser H, Pichler M (1977) Gerinungsstörungen im Rahmen der Hämoperfusion. Wien Klin Wochenschr 89: 347–350

    Google Scholar 

  • Sangster B, Heijst ANP van, Sixma J (1981) The influence of haemoperfusion on haemostasis and cellulose constituents of the blood in the treatment of intoxications. Arch Toxicol 47: 269–278

    Google Scholar 

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Rommes, J.H., Sangster, B., Gmelig Meyling, F.H.J. et al. The influence of haemoperfusion on white cells, immunoglobulin concentrations and the complementsystem in the treatment of intoxications. Arch Toxicol 52, 149–156 (1983). https://doi.org/10.1007/BF00354774

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  • DOI: https://doi.org/10.1007/BF00354774

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