Summary
After lysine addition to an exponentially growing culture of Escherichia coli K12, the kinetics of repression of aspartokinase III synthesis show a transient regulatory phenomenon: during one generation, enzyme synthesis is practically equal to zero (Fig. 1). A similar phenomenon appears to be involved during repression of aspartokinase I-homoserine dehydrogenase I synthesis by threonine and isoleucine (Fig. 2). This sort of phenomenon has been previously reported in another system and interpreted as an indication of regulation at the translational level.
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Communicated by F. Gros
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Boy, E., Theze, J. & Patte, J.C. Transient regulation of enzyme synthesis in Escherichia coli . Molec. gen. Genet. 121, 77–81 (1973). https://doi.org/10.1007/BF00353695
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DOI: https://doi.org/10.1007/BF00353695