Skip to main content
SpringerLink
Log in

On nickel contents in urine and hair in a case of exposure to nickel carbonyl

  • Published:
Archives of Toxicology Aims and scope Submit manuscript

Abstract

In an accidental case of exposure to nickel carbonyl with a few persons weak symptoms of illness were observed. Rapid and simple methods of flameless atomic absorption spectroscopy were applied for the determination of nickel in urinary samples and in sections of bundled hairs. The measurements showed in some cases remarkable increased Ni values well above normal levels. The data obtained will be amply discussed and can be used in part for a rough estimation of the biological half life of inhaled Ni.

Zusammenfassung

Bei einer unfallbedingten Einwirkung von Nickelcarbonyl wurden bei einigen Personen leichte Krankheitssymptome beobachtet. Rasche und einfache Methoden der flammenlosen Atomabsorptionsspektrometrie wurden zur Bestimmung von Nickel in Harn und in Abschnitten geordneter Haarbüschel angewandt. Die Messungen ergaben in einigen Fällen erheblich über dem Normalpegel liegende Nickelwerte. Die erhaltenen Daten werden ausführlich diskutiert, sie können teilweise zur ungefähren Abschätzung der biologischen Halbwertszeit des eingeatmeten Nickels herangezogen werden.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ader, D., Stoeppler, M.: Radiochemical and methodological studies on the recovery and analysis of nickel in urine. J. Analyt. Toxicol. (in press) (1978)

  • Armit, H. W.: The toxicology of nickel carbonyl. Part I, J. Hyg. 7, 525 (1907), Part II, ibid. 8, 565 (1908)

    Google Scholar 

  • Alder, J. F., Samuel, A. J., West, T. S.: The single element determination of trace metals in hair by carbon-furnace atomic absorption spectrometry. Anal. Chim. Acta 87, 313 (1976)

    Google Scholar 

  • Bate, L. C., Dyer, F. F.: Trace elements in human hair. Nucleonics 23, 74 (1965)

    Google Scholar 

  • Bate, L. C.: Adsorption and elution of trace elements on human hair. Int. J. appl. Rad. Isot. 17, 417 (1966)

    Google Scholar 

  • Creason, J. P., Hinners, T. A., Bumgarner, J. E., Pinkerton, C.: Trace elements in hair, as related to exposure in metropolitan New York. Clin. Chem. 21, 603 (1975)

    Google Scholar 

  • Diem, K., Lentner, C. (eds.): Documenta Geigy, Wissenschaftliche Tabellen. Stuttgart: Huber 1975

    Google Scholar 

  • Forslev, A. W.: “Non-destructive” neutron analysis of hair. J. forens. Sci. 11, 217 (1966)

    Google Scholar 

  • Hagedorn-Götz, H., Stoeppler, M.: Zum forensischen Nachweis von Thallium in menschlichen Haaren durch flammenlose Atomabsorptionsspektrometrie. Arch. Toxicol. 34, 17 (1975)

    Google Scholar 

  • Henke, G., Bohn, G.: Zum Nachweis einer zweimaligen Thalliumvergiftung durch aktivierungsanalytische Untersuchung von Haaren und Nägeln. Arch. Toxikol. 25, 48 (1969)

    Google Scholar 

  • Henke, G., Fitzek, A.: Nachweis von Thalliumvergiftung durch Neutronenaktivierungsanalyse. Arch. Toxikol. 27, 266 (1971)

    Google Scholar 

  • Henschler, D.: Gesundheitsschädliche Arbeitsstoffe, Nickelcarbonyl, Weinheim: Verlag Chemie 1974

    Google Scholar 

  • Horak, E., Sunderman, Jr., F.W., Nechay, M. W., McNeely, M. D.: Fecal nickel excretion by healthy adults. Clin. Chem. 19, 429 (1973)

    Google Scholar 

  • Kincaid, J. F., Stanley, E. L., Beckworth, C. H., Sunderman, F. W.: Nickel poisoning. III. Procedures for detection, prevention, and treatment of nickel carbonyl exposure including a method for the determination of nickel in biological material. Amer. J. Clin. Path. 26, 107 (1956)

    Google Scholar 

  • Kleavy, L. M.: Hair as a biopsy material. III. Assessment of environmental lead exposure. Arch. environm. Hlth 26, 169 (1973)

    Google Scholar 

  • Kopito, L., Byers, R. K., Shwachman, H.: Lead in hair of children with chronic lead poisoning. New Engl. J. Med. 276, 949 (1967)

    Google Scholar 

  • Ludewigs, H. J., Thiess, A. M.: Arbeitsmedizinische Erkenntnisse bei der Nickelcarbonylvergiftung. Zbl. Arbeitsmed. 20, 329 (1970)

    Google Scholar 

  • Maes, D., Adiwinata, Y., Egglestone, D., Fyles, T., Pate, B. D.: “Finger-printing” of hair and oil by flameless A.A. 4th Int. Conf. on Atomic Spectroscopy, Toronto, Oct. 29th to Nov., 2nd, 1973

  • McNeely, M. D., Nechay, M. W., Sunderman, Jr., F. W.: Measurements of nickel in serum and urine as indices of environmental exposure to nickel. Clin. Chem. 18, 992 (1972)

    Google Scholar 

  • Morgan, J. G.: A simplified method for the estimation of nickel in urine. Brit. J. industr. Med. 17, 209 (1960)

    Google Scholar 

  • Nechay, M. W., Sunderman, Jr., F. W.: Measurements of nickel in hair by AAS. Ann. clin. Lab. Sci. 3, 30 (1973)

    Google Scholar 

  • Nomoto, S., Sunderman, Jr., F. W.: Atomic absorption spectrometry of nickel in serum, urine, and other biological materials. Clin. Chem. 16, 477 (1970)

    Google Scholar 

  • Nord, P. J., Kadaba, M. P., Sorenson, J. R. J.: Mercury in human hair. Arch. environm. Hlth 27, 40 (1973)

    Google Scholar 

  • Pate, B. D.: Private communication (1973)

  • Perry, Jr., H. M., Perry, E. F.: Normal concentrations of some trace metals in human urine: changes produced by ethylenediaminetetraacetate. J. clin. Invest. 38, 1452 (1959)

    Google Scholar 

  • Schroeder, H. A., Balassa, J. J., Tipton, I. H.: Abnormal trace metals in men — nickel. J. chron. Dis. 15, 51 (1961)

    Google Scholar 

  • Schroeder, H. A., Nason, A. P.: Trace metals in human hair. J. invest. Derm. 53, 71 (1969)

    Google Scholar 

  • Stoeppler, M.: Unpublished work

  • Sunderman, F. W., Kincaid, J. F.: Nickel poisoning. II. Studies on patients suffering from acute exposure to vapors of nickel carbonyl. J. Amer. med. Ass. 155, 889 (1954)

    Google Scholar 

  • Sunderman, Jr., F.W.: Measurements of nickel in biological materials by atomic absorption spectrometry. Amer. J. clin. Path. 44, 182 (1965)

    Google Scholar 

  • West, B., Sunderman, F. W.: Nickel poisoning. VI. A note concerning the ineffectiveness of Edathamil Calcium-Disodium. Arch. industr. Hlth 18, 480 (1958)

    Google Scholar 

  • Weinig, E., Schmidt, G.: Zur Verteilung des Thalliums bei tödlichen Thalliumvergiftungen. Arch. Toxikol. 21, 199 (1966)

    Google Scholar 

  • Zachariasen, H., Andersen, J., Kostol, C., Barton, R.: Technique for determining nickel in blood by flameless atomic absorption spectrophotometry. Clin. Chem. 21, 562 (1975)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nuclear Research Centre (KFA), Institute of Chemistry, Institute 4 Applied Physical Chemistry, P.O.Box 1913, D-5170, Jülich 1, Federal Republic of Germany

    H. Hagedorn-Götz, G. Küppers & M. Stoeppler

Authors
  1. H. Hagedorn-Götz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Küppers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Stoeppler
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Now: Chemical Analysis Unit

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hagedorn-Götz, H., Küppers, G. & Stoeppler, M. On nickel contents in urine and hair in a case of exposure to nickel carbonyl. Arch. Toxicol. 38, 275–285 (1977). https://doi.org/10.1007/BF00352032

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00352032

Key words

Schlüsselwörter

Search

Navigation