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Regional pre- and postganglionic sympathetic activity during experimental paraoxon poisoning

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Abstract

The effects of 0.4 or 0.8 mg paraoxon/kg i.v. on circulation and regional pre- and postganglionic sympathetic activity were studied in anaesthetized rabbits. At both doses, the discharges of the preganglionic efferents increased slowly, whereas the changes in activity of postganglionic efferents differed. Concomitantly with a transient initial rise in blood pressure a temporary increase of discharges to the skeletal muscles and to the intestine was observed which is attributed to spontaneous firing of the regional ganglionic cells. After injection of 0.4 mg/kg there occasionally occurred a second pressor reaction conditioned by enhancement of preganglionic activity and facilitated transmission in certain sympathetic ganglia.

After injection of the higher dose, postganglionic activity generally decreased except for the discharges of gastrointestinal efferents, which increased. Arterial blood pressure, cardiac output and total peripheral resistance fell markedly. A shock syndrome occurred which could be controlled by atropine injection if timely. From the results it was concluded that the higher dose of paraoxon blocked synaptic transmission in the paravertebral ganglia of the sympathetic trunk, and facilitated impulse transmission in the prevertebral abdominal ganglia.

Zusammenfassung

An narkotisierten Kaninchen wurde die Wirkung von 0,4 oder 0,8 mg Paraoxon/kg i.v. auf Kreislaufwerte und prä- und postganglionäre Sympathikusaktivität verschiedener Körpergebiete untersucht. Die Aktivität in präganglionären Sympathikusefferenzen nahm bei beiden Dosierungen langsam zu, während in den postganglionären Efferenzen teilweise gegensinnige Aktivitätsänderungen auftraten. Gleichzeitig mit einem flüchtigen initialen Blutdruckanstieg wurde eine vorübergehende Aktivitätszunahme in Sympathikusefferenzen zur Skelettmuskulatur und zum Intestinum beobachtet, die auf Spontanentladungen in den regionalen Ganglien zurückgeführt wird. Nach Injektion von 0,4 mg/kg kam es gelegentlich zu einer zweiten pressorischen Reaktion, die durch Zunahme der präganglionären Aktivität bei erleichterter Erregungsübertragung in bestimmten Sympathikusganglien bedingt war.

Nach Injektion der höheren Dosis wurde postganglionär überwiegend eine Aktivitätsabnahme beobachtet; nur die Entladungen gastrointestinaler Sympathikusefferenzen nahmen noch zu. Arterieller Blutdruck, Herzminutenvolumen und peripherer Gesamtwiderstand fielen stark ab. Es trat ein Schocksyndrom auf, das sich durch rechtzeitige Atropininjektion beherrschen ließ. Aus den Ergebnissen wird geschlossen, daß Paraoxon in höherer Dosis die Erregungsübertragung in den paravertebralen Grenzstrangganglien blockierte und die synaptische Übertragung in den prävertebralen Abdominalganglien erleichterte.

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Authors and Affiliations

  1. Pharmakologisches Institut der Rheinischen Friedrich-Wilhelms-Universität, Reuterstraße 2b, D-5300, Bonn 1, Germany

    R. Kullmann & Uta Uerdingen

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  1. R. Kullmann
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  2. Uta Uerdingen
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The authors dedicate this work in gratitude to Professor Dr. R. Domenjoz, on the occasion of his seventieth birthday

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Kullmann, R., Uerdingen, U. Regional pre- and postganglionic sympathetic activity during experimental paraoxon poisoning. Arch. Toxicol. 41, 49–60 (1978). https://doi.org/10.1007/BF00351769

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