Abstract
Initiating effects of the fumigant 1,2-dibromoethane (DBE) for liver were examined using the Solt-Farber selection system. Male Sprague Dawley rats (230–260 g) were given one oral dose of DBE (75 mg/kg), a two-thirds partial hepatectomy 4 h later, five oral doses of 2-acetylamidofluorene (AAF) (25 mg/kg) on days 17-21, CC14 (2 ml/kg) on day 22, a booster dose of AAF (10 mg/kg) on day 32, and were sacrificed on day 82. Nodules and appreciable gamma-glutamyl transpeptidase foci were found in the livers of four of six animals given DBE, but not in any animals of the control group.
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Moslen, M.T., Ahluwalia, M.B. & Farber, E. 1,2-Dibromoethane initiation of hepatic nodules in Sprague-Dawley rats selected with Solt-Farber system. Arch Toxicol 58, 118–119 (1985). https://doi.org/10.1007/BF00348321
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DOI: https://doi.org/10.1007/BF00348321