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Effect of prostaglandin E1 on cerebral circulatory disturbances following subarachnoid haemorrage in man

Effets de la prostaglandine E1 sur les troubles circulatoires cerebraux consecutifs a l'hemorragie meningee chez l'homme

Einfluß von Prostaglandin E1 bei cerebralen Durchblutungsveränderungen nach einer Subarachnoidealblutung

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Summary

The effect of intracarotid injection of prostaglandin E1 on the cerebral haemodynamics in subarachnoid bleeding has been studied in 6 patients. The dose rate ranged from 0.000002 μg/kg/min–0.03 μg/kg/min. Arterial diameter, cerebral blood flow and circulation times were measured and blood pressure, respiration and electrocardiographic changes were monitored.

No definite spasmolytic effects were observed and no major adverse reactions were encountered.

Résumé

Les auteurs ont étudié l'effet de l'injection intracarotidienne de Prostaglandine E1 sur l'hémodynamique cérébrale dans les hémorragies méningées chez six patients. Le dosage s'échelonne entre 0.000002 μg/kg/mn 0.03 μg/kg/mn. Le diamètre artériel, le flux sanguin cérébral et le temps circulatoire furent mesurés, la pression sanguine, la respiration et l'activité électrocardiographique furent enregistrées. On n'observa aucun effet spasmolytique précis, ni aucune réaction d'intolérance majeure.

Zusammenfassung

Prostaglandin E1 ist eine vasoaktive Substanz. Bei Infusionen in die A. carotis am Hund konnte eine cerebrale Gefäßerweiterung beobachtet werden. Bei intracarotidealer Injektion beim Menschen jedoch waren keine sicheren spasmolytischen Effekte nachweisbar.

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Authors and Affiliations

  1. Departments of Neurosurgery and Neuroradiology, Karolinska Sjukhuset and King Gustav Vth Research Institute, Stockholm

    L. Steiner, D. M. C. Forster, U. Bergvall & L. A. Carlson

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  1. L. Steiner
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  2. D. M. C. Forster
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  3. U. Bergvall
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  4. L. A. Carlson
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Steiner, L., Forster, D.M.C., Bergvall, U. et al. Effect of prostaglandin E1 on cerebral circulatory disturbances following subarachnoid haemorrage in man. Neuroradiology 4, 20–24 (1972). https://doi.org/10.1007/BF00344804

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