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Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate

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Abstract

Intoxication of male rats with 5 mg/kg parathion reduces survival to 15%. Diethyldithiocarbamate (DDC), known to inhibit mixed-function oxidase activity, has no effect on survival rate when this compound is used in a dosage of 300 mg/kg 45 min before or 10 min after parathion intoxication. However, when DDC and parathion are administered simultaneously, the rate of survival rises to 53%.

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References

  • Alary JD, Brodeur J (1969) Studies on the mechanism of phenobarbital-induced protection against parathion, in adult female rats. J Pharmacol Exp Ther 169: 159–167

    Google Scholar 

  • Aldridge WN (1953) Serum esterases. 2. An enzyme hydrolizing p-nitrophenyl phosphate (E600) and its identity with the A-esterase of mammalian sera. Biochem J 53: 117–124

    Google Scholar 

  • Chapman SK, Leibman KC (1971) The effect of chlordane, DDT and 3-methylcholantrene upon the metabolism and toxicity of diethyl-4-nitrophenyl phosphorothionate. Toxicol Appl Pharmacol 18: 977–987

    Google Scholar 

  • Gage JC (1953) A cholinesterase inhibitor derived from 0,0-diethyl O-p-nitrophenyl thiophosphate in vivo. Biochem J 54: 426–430

    Google Scholar 

  • O'Brien RD (1959) Activation of thionophosphates by liver microsomes. Nature 183: 121–122

    Google Scholar 

  • Masuda Y, Nakayama N (1982) Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents. Biochem Pharmacol 31: 2713–2725

    Google Scholar 

  • Lang M, Marselos M, Törrönen R (1976) Modifications of drug metabolism by disulfiram and diethyldithiocarbamate I. Mixed-function oxygenase. Chem-Biol Interact 15: 267–276

    Google Scholar 

  • Lutz LM, Glende jr EA, Recknagel RO (1973) Protection by diethyldithiocarbamate against carbon tetrachloride lethality in rats and against carbon tetrachloride-induced lipid peroxidation in vitro. Biochem Pharmacol 22: 1729–1734

    Google Scholar 

  • Neal RA (1967a) Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro. Biochem J 103: 183–191

    Google Scholar 

  • Neal RA (1967b) Studies of the enzymic mechanism of the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) by rat liver microsomes. Biochem J 105: 289–297

    Google Scholar 

  • Strubelt O, Siegers CP, Schutt A (1974) The curative effects of cysteamine, cysteine and dithiocarb in experimental paracetamol poisoning. Arch Toxicol 33: 55–64

    Google Scholar 

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Homann, J., Schneider, S. & Matthes, KJ. Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate. Arch Toxicol 57, 144–145 (1985). https://doi.org/10.1007/BF00343127

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  • DOI: https://doi.org/10.1007/BF00343127

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