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Dimethoate-induced toxic cardiac failure in the guinea pig

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Abstract

In anaesthetized guinea-pigs treated with lethal doses of dimethoate, cardiac failure and serious ECG disturbances developed in the early phase of intoxication. The toxic cardiac phenomena appeared to be unrelated to the degree of cholinesterase inhibition, but showed a close correlation with myocardial dimethoate concentration. Cardiac failure and mortality were first observed at a critical pesticide level of about 110 μg/g, while a level of 221 μg/g resulted in death in all cases. The present investigation refers to the direct effect of the pesticide on the myocardium, independent of its anticholinesterase action.

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Authors and Affiliations

  1. Internal Intensive Care Unit, Department of Pharmacodynamics, Department of Hygiene and Epidemiology, Department of Pathology, University Medical School, H-6701, Szeged, Hungary

    György Marosi, János Iván, László Nagymajtényi & Anna Tószegi

  2. Plant Protection and Agrochemical Station, Hódmezővásárhely, Hungary

    Imre Csatlós

Authors
  1. György Marosi
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  2. János Iván
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  3. László Nagymajtényi
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  4. Imre Csatlós
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  5. Anna Tószegi
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Marosi, G., Iván, J., Nagymajtényi, L. et al. Dimethoate-induced toxic cardiac failure in the guinea pig. Arch Toxicol 57, 142–143 (1985). https://doi.org/10.1007/BF00343126

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  • DOI: https://doi.org/10.1007/BF00343126

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