Abstract
Human fetal liver microsomes were found to metabolize the carcinogen 2-acetylaminoflurene (AAF), the major metabolite being the deacetylated product 2-aminofluorene (AF). On the other hand, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), a proximate carcinogenic metabolite, could not be detected. The human fetal liver samples converted AF and N-OH-AAF, but not AAF, to products mutagenic for S. typhimurium TA 98.
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Aune, T., Haugen, A. & Dybing, E. Metabolism and mutagenicity of aromatic amines by human fetal liver. Arch Toxicol 57, 136–138 (1985). https://doi.org/10.1007/BF00343124
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DOI: https://doi.org/10.1007/BF00343124