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Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2

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Summary

Mutations in a known yeast gene, ADE3, were shown to act as an antisuppressor, reducing the efficiency of the omnipotent suppressor, sup45-2. The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNAfmet. The role of this enzyme in translational fidelity had not previously been suspected.

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Authors and Affiliations

  1. Laboratory for Cell Molecular and Developmental Biology, Department of Biological Sciences, University of Illinois at Chicago, Box 4348, 60680, Chicago, IL, USA

    Jae Mahn Song & Susan W. Liebman

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  1. Jae Mahn Song
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  2. Susan W. Liebman
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Song, J.M., Liebman, S.W. Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2 . Curr Genet 16, 315–321 (1989). https://doi.org/10.1007/BF00340709

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  • DOI: https://doi.org/10.1007/BF00340709

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