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On modelling the variability of interspike intervals during epileptic unit activity

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Abstract

In spite of the fact that the participation of well defined ionic particles in generating convulsive unit discharges is established, there is a gap between the data on ionic movements and on first-order statistics of firing patterns. Our aim was to tight this gap by studying the effectiveness of functionally separated electrical conductances of membrane during the generation of consecutive interspike interval histograms (IIHs) of unitary discharges. On account of the non-stationarity of the process curve fitting analysis which based on the simple modifications of the integrate-and-fire model has been implemented in the sequential interspike interval histogram procedure (SIIH). The experimental data were recorded from cat cortex treated with 3-Aminopyridine (3-Ap) by glass microelectrodes during nembutal anesthezia. Assuming the normal distribution of input parameters it is concluded, that the efficiency of the fluctuations of the active spike-generating conductance g g and the passive diffusional conductance g l may increase during the generation of the unimodal IIHs and the first mode of the bimodal IIHs. The simple conductance coupling g l =a·g g +b may participate in g l activation, moreover, the reciprocally coupled mechanism g g =c/g l may be driven by g l activation (a, b, c are the coupling constants). A temporal separation of processes governed by g g or g l respectively was observed. The timeindependent occurrences of the reciprocally coupled conductance processes may be involved in the unit activities represented by the prolonged IIHs and second modes of the bimodal IIHs.

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  1. Department of Comparative Physiology, Attila József University, Szeged, Hungary

    F. Pongrácz & Magdolna Szente

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  1. F. Pongrácz
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  2. Magdolna Szente
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Pongrácz, F., Szente, M. On modelling the variability of interspike intervals during epileptic unit activity. Biol. Cybern. 41, 165–177 (1981). https://doi.org/10.1007/BF00340318

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