Summary
The belief that a neoplastic cell develops from a normal progenitor due to structural changes in DNA has been a fundamental basis of the study of the molecular biology of cancer. Recent technical advances in this field will give rise to conceptual advances and there is every reason to believe that a new field of cancer genetics is emerging, named here “Oncogenetics”: a branch of genetics describing the cause of effects of genes causing neoplasia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alitalo K (1984) Amplification of cellular oncogenes in cancer cells. Med Biol 62: 304–317
Ascione R, Sacchi N, Watson DK, Fisher RF, Fujiwara S, Seth A, Papas TS (1986) Oncogenes: Molecular probes for clinical application in malignant disease. Gene Anal Tech 3:25–39
Baltimore D (1970) Viral RNA-dependent DNA polymerase. Nature 226:1209–1211
Bishop JM (1983) Cancer genes come of age. Cell 32:1018
Blair DG, Cooper CS, Oskarrson MK, Eader LA, Vande Wounde GF (1982) New method for detecting cellular tranforming genes. Science 218:1122–1124
Boveri T (1902) Über mehrpolige Mitosen als Mittel zur Analyse des Zellkerns. Verh Phys Med Ges Würzburg 35:67–90
Boveri T (1914) Zur Frage der Entstehung maligner Tumoren. Gustay Fischer, Verlag, Jena
Burnet FM (1976) Immunology, aging and cancer. W.H. Freeman, San Francisco, p 136
Cavenee WK, Murphree L, Shull MM, Benedict WF, Sparks RS, Kock E, Nordenskjold M (1986) Prediction of familial predisposition of retinoblastoma. N Engl J Med 314:1201–1207
Chattopadhyay SK, Chang EH, Lander MR, Elis RW, Scolnick EM, Lowy DR (1982) Amplification and rearrangement of onc genes in mammalian species. Nature 296:361–363
Deuel TF, Huang JS (1984) Roles of growth factor activities in oncogenesis. Blood 64:951–954
Dulbecco R (1986) A turning point in cancer research. Sequencing the human genome. Science 231:1055–1056
Ellerman V, Bang O (1908) Experimentelle Leukämie bei Hühnern. Centralbl Bakterid 46:595–609
Gilbert F (1983) Chromosome aberrations and oncogenes. Nature 303:475
Gordon H (1985) Oncogenes. Mayo Clin Proc 60:697–713
Green AR, Wyke JA (1985) Anti-oncogenes. A subset of regulatory genes involved in carcinogenesis. Lancet III 475–477
Hansemann D (1890) Über asymmetrische Zellteilung in Epithelkrebsen und deren biologische Bedeutung. Virchows Arch Pathol Anat 119:299–326
Hayward WS, Neel BG, Astrin SM (1981) Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475–480
Klein G, Klein E (1985) Evolution of tumors and the impact of molecular oncology. Nature 315:190–195
Klein G, Klein E (1986) Conditioned tumorigenicity of activated endogenes. Cancer Res
Land H, Parada LF, Weinberg RA (1983) Cellular oncogenes and multistep carcinogenesis. Science 222:771
Lebeau MM, Rowley JD (1986) Chromosomal abnormalities in leukemia and lymphoma: Clinical and biological significance. Adv Hum Genet 15:1–54
McClain KL (1984) Expressions of oncogenes in human leukemias. Cancer Res 44:5382–5389
McKusick VA (1985) Marcella O'Grady Boveri (1865–1950) and the chromosome theory of cancer. J Med Genet 22:431–440
Nowell PC, Hungerford DA (1960) A minute chromosome in human chronic granulocytic leukemia. Science 132:1497
Pearson M, Rowley JD (1985) The relation of oncogenesis and cytogenetics in leukemia and lymphoma. Annu Rev Med 36:471–483
Pereira-Smith OM, Smith JR (1983) Evidence for the recessive nature of cellular immortality. Science 221:964–966
Rous P (1911) Transmission of amalignant new growth by means of a cell free filterate. JAMA 56:198
Rubin H (1984) Mutation and oncogenes-cause or effect. Nature 309:518
Sandberg AA (1983) A chromosomal hypothesis of oncogenesis cancer. Genet Cytogenet 8:277–285
Schimke RT (1982) Gene amplification. Cold Spring Harbor, NY
Slamon DJ, de Kernion JB, Verma IM, Cline MJ (1984) Expression of cellular oncogenes in human malignancies. Science 224:256–262
Temin HM, Mißutan S (1970) RNA dependent DNA polymerase in virions of rous sarcoma virus. Nature 226:1211–1213
Varmus HE (1984) The molecular genetics of cellular oncogenes. Annu Rev Genet 18 553–612
Varma RS (1987) Chromosomal abnormalities in neoplastic diseases. In: Rosenthal (ed) Manual of clinical oncology, C.I. Elsevier Scientific, New York (in press)
Verma RS, Kopelwitz N (1985) Oncogenesis of retinoblastoma. Ann Ophthalmol 17:701–703
Waldmann TA (1986) The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes. Science 232:727–732
Weinberg RA (1983) A molecular basis of cancer. Sci Am 249:126–142
Weinberg RA (1985) Oncogenes and the molecular roots of cancer. Adv Oncol 1:2–8
Winge O (1930) Zytologische Untersuchungen über die Natur maligner Tumore. Teerkarzinome bei Mäusen. Z Zellforsch 10:683–735
Yunis JJ (1983) The chromosomal basis of human neoplasia. Science 221:227–236
Yunis JJ (1986) Chromosomal rearrangements, genes, and fragile sites in cancer. Clinical and biological implications In: Devita VT, Hellmann S, Rosenberg SA (eds) Important advances in oncology. Lippinott Co, Philadelphia, Pennsylvania, pp 93–127
Author information
Authors and Affiliations
Additional information
Communicated by K. Illmensee
Rights and permissions
About this article
Cite this article
Verma, R.S. Oncogenetics. Mol Gen Genet 205, 385–389 (1986). https://doi.org/10.1007/BF00338071
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00338071