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L'ultrastructure du foie humain lors d'ictères idiopathiques chroniques

IV. Mitochondries de morphologie Inhabituelle et «inclusions cytoplasmiques paracristallines» hépatocytaires

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Summary

The hepatocytes of 15 liver biopsies from 13 patients suffering from nonhemolytic constitutional jaundice were studied with respect to the presence of mitochondria with fibrillary inclusions or with vacuoles and to the presence of «paracrystalline cytoplasmic inclusions».

Intramitochondrial fibrillary inclusions were found in all cases in quite various proportions, from 1 to 45% of the observed organelles. Intramitochondrial vacuoles were less frequent: they were observed only in three cases, and in one case only in more than 10% of the organelles. Mugnaini's paracrystalline inclusions, dispersed in the cytoplasm of the hepatocytes without outer membranes, were abundant in two cases.

None of these morphological characters could be considered as pathognomonic and their origin is unknown: nevertheless their repartition in human liver in pathological conditions seems worthy of further study.

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Bibliographie

  • André, J.: Contribution à la connaissance du chondriome. J. Ultrastruct. Res., Suppl. 3, 1–185 (1962).

    Article  Google Scholar 

  • Barone, P.: Colostasi intracellulare pura. Virchows Arch. path. Anat. 341, 43–53 (1966).

    Article  CAS  Google Scholar 

  • —, C. Inferrera e F. Tigano: Studio clinico, istochimico ed ultrastrutturale su due casi di sindrome di Dubin-Johnson-Rotor. Anatomia 39, 431–478 (1966).

    Google Scholar 

  • Behnke, O.: Helical filaments in rat liver mitochondria. Exp. Cell Res. 37, 687–689 (1965).

    Article  CAS  PubMed  Google Scholar 

  • Biempica, L.: Human hepatic microbodies with crystalloid cores. J. Cell Biol. 29, 383–386 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carruthers, J. S., and J. W. Steiner: Experimental extrahepatic biliary obstruction. Gastroenterology 42, 419–430 (1962).

    CAS  PubMed  Google Scholar 

  • Cossel, L.: Die menschliche Leber im Elektronenmikroskop. Jena: Gustav Fischer 1964.

    Google Scholar 

  • Cussac, Y., A. Porte, J. C. Mandard, R. Voegtlin, J. P. Carbillet et L. Toujas: Modifications ultrastructurales des hépatocytes dans un cas d'ictère chronique idiopathique de type Dubin-Johnson. Ann. Anat. path. 11, 37–54 (1966).

    CAS  Google Scholar 

  • David, H.: Submikroskopische Ortho- und Pathomorphologie der Leber. Berlin: Akademie Verlag 1964.

    Google Scholar 

  • FahrlÄnder, H., F. Huber, and F. Gloor: Intrahepatic retention of bile in severe bacterial infections. Gastroenterology 47, 590–599 (1964).

    Google Scholar 

  • Holle, G.: Pathologische Ultrastruktur der Leber. In: G. A. Martini, Aktuelle Probleme der Hepatologie, S. 8–21. Stuttgart: Georg Thieme 1962.

    Google Scholar 

  • Hruban, Z., and H. Swift: Uricase: localization in hepatic microbodies. Science 146, 1316–1318 (1964).

    Article  CAS  PubMed  Google Scholar 

  • Jean, G., G. Lambertenghi e P. Travaglini: Contributi apportati dalla microscopia elettronica allo studio delle epatopatie. Gaz. sanit. 37, 18–23 (1966).

    Google Scholar 

  • Jézéquel, A.-M.: Dégénérescence myélinique des mitochondries du foie humain dans un épithélioma du cholédoque et un ictère viral. J. Ultrastruct. Res. 3, 210–215 (1959).

    Article  PubMed  Google Scholar 

  • Laguens, R., and N. Bianchi: Fine structure of the liver in human idiopathic diabetes mellitus (I). Exp. molec. Path. 2, 203–214 (1963).

    Article  CAS  PubMed  Google Scholar 

  • Lombardi, L.: La structure des crêtes mitochondriales du rein de souris après fixation aldéhydique. J. Microscopie 5, 453–470 (1966).

    Google Scholar 

  • Malhotra, S. H.: A study of the mitochondrial membrane system. J. Ultrastruct. Res. 15, 14–37 (1966).

    Article  CAS  PubMed  Google Scholar 

  • Maunsbach, A. B.: Electron microscopic observations of cytoplasmic bodies with crystalline patterns in rat kidney proximal tubule cells. J. Ultrastruct. Res. 14, 167–189 (1966).

    Article  Google Scholar 

  • Merlini, D.: Ultrastruttura della cellula epatica in condizioni normali e in alcune condizioni patologiche. Relazione al IV Symposium internat. di epatologia, 28–29. 6. 1965, Chianciano Terme.

  • Minio, F., G. Aliberti, D. Gardiol, A. Gautier, P. Magnenat et A. Torsoli: L'ultrastructure du foie humain lors d'ictères idiopathiques chroniques (II). Z. Zellforsch. 66, 496–503 (1965a).

    Article  CAS  PubMed  Google Scholar 

  • —, A. Gautier et P. Magnenat: L'ultrastructure du foie humain lors d'ictères idiopathiques chroniques (III). Z. Zellforsch. 72, 168–183 (1966a).

    Article  CAS  PubMed  Google Scholar 

  • - - A. Torsoli, D. Gardiol et P. Magnenat: L'ultrastructure du foie humain lors d'ictères idiopathiques chroniques. Acta tertii conv. med. intern, hung., p. 395–405. Budapest 1965b.

  • —, P. Magnenat, D. Gardiol et A. Gautier: L'ultrastructure du foie humain lors d'ictères idiopathiques chroniques (I). Z. Zellforsch. 65, 47–56 (1965c).

    Article  Google Scholar 

  • —, et A. Gautier: L'ultrastructure du foie humain lors d'ictères non hémolytiques chroniques congénitaux. Rev. int. Hépat. 16, 323–329 (1966b).

    CAS  PubMed  Google Scholar 

  • Mölbert, E., u. R. Marx: Elektronenmikroskopische Untersuchungen am Lebergewebe beim Rotor-Syndrom. Acta hepato-splenol. (Stuttg.) 13, 160–175 (1966).

    Google Scholar 

  • Mugnaini, E.: Filamentous inclusions in the matrix of mitochondria from human livers. J. Ultrastruct. Res. 11, 525–544 (1964).

    Article  CAS  PubMed  Google Scholar 

  • Orlandi, F.: Electron-microscopic observations on human liver during cholestasis. Acta hepato-splenol. (Stuttg.) 9, 155–164 (1962).

    CAS  Google Scholar 

  • —, and A.-M. Jézéquel: Electron microscopy of the human liver after methandrostenolone administration. In: G. A. Martini, Aktuelle Probleme der Hepatologie, S. 41–47. Stuttgart: Georg Thieme 1962.

    Google Scholar 

  • Picardi, R.: Comm. pers. 1966.

  • Rouiller, C., and A.-M. Jézéquel: Electron microscopy of the liver. In: C. Rouiller, The liver, p. 208. New York and London: Academic Press 1963.

    Google Scholar 

  • Salomon, J. C., et A.-M. Jézéquel: Ultrastructure des hépatomes expérimentaux. In: Les tumeurs malignes du foie, p. 63–96. Paris: Masson & Cie. 1963.

    Google Scholar 

  • Stephens, R. J., and R. F. Bils: An atypical mitochondrial form in normal rat liver. J. Cell Biol. 24, 500–504 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Svoboda, D. J., and R. T. Manning: Chronic alcoholism with fatty metamorphosis of the liver. Amer. J. Path. 44, 645–662 (1964).

    CAS  PubMed  PubMed Central  Google Scholar 

  • Torsoli, A., P. Magnenat, G. Aliberti et F. Minio: Etude clinique et ultrastructurelle de deux cas d'ictère non hémolytique chronique à bilirubine directe avec foie macroscopiquement normal. Acta tertii conv. med. intern. hung., p. 428–432. Budapest 1965a.

  • —, F. Minio, G. Aliberti e A. Gautier: Rilievi clinici e de microscopia elettronica in due casi di ittero idiopatico cronico anemolitico a bilirubina diretta, senza signi macroscopici di anomale pigmentazione epatica. Arch. ital. Mal. Appar. dig. 32, 152–160 (1965b).

    CAS  PubMed  Google Scholar 

  • Tsukuda, H., Y. Mochizuki, and S. Fujiwara: The nucleoids of rat liver cells microbodies. J. Cell Biol. 28, 449–460 (1966).

    Article  Google Scholar 

  • Watrach, A. M.: Degeneration of mitochondria in lead poisoning. J. Ultrastract. Res. 10, 177–181 (1964).

    Article  CAS  Google Scholar 

  • Wills, E. J.: Crystalline structures in the mitochondria of normal human liver parenchymal cells. J. Cell Biol. 24, 511–514 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wood, R. L.: The fine structure of hepatic cells in chronic ethionine poisoning and during recovery. Amer. J. Path. 46, 307–330 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Centre de Microscopie Electronique de l'Université de Lausanne, Suisse

    F. Minio & A. Gautier

  2. Istituto di Patologia Medica, Policlinico Umberto I Università di Roma, Roma, Italia

    F. Minio

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  1. F. Minio
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  2. A. Gautier
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Travail subventionné par le «Fonds National Suisse de la Recherche Scientifique».

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Minio, F., Gautier, A. L'ultrastructure du foie humain lors d'ictères idiopathiques chroniques. Z. Zellforsch. 78, 267–279 (1967). https://doi.org/10.1007/BF00334767

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  • DOI: https://doi.org/10.1007/BF00334767

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