Abstract
The content of thallium in seven body organs and eight brain regions of rats acutely exposed to Tl2SO4 was compared. Rats received a single i.p. injection of Tl2SO4 at three doses: 16, 32 and 48 mg/kg. At 24 h after treatment, thallium content in kidney was higher than in all other organs studied and whole brain had the lowest thallium concentration. A thallium differential distribution was found among brain regions. The highest thallium concentration was found in the hypothalamus and the lowest in the cortex. This distribution pattern was similar with the three doses used. Time course of thallium accumulation in brain was found to be considerably more rapid in the hypothalamus than in other regions, particularly the cortex, suggesting differences in thallium entry into brain parenchyma. Thallium brain regional differential distribution might be related to some of the symptoms of thallium central neurotoxicity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Achenbach C, Hauswirth O, Heidrichs C, Ziskoven R, Kohler F, Bahr U, Heidrichs A, Schulten H-R (1980) Quantitative measurement of time dependent thallium distribution in organs of mice by field desorption mass spectrometry. J Toxicol Environ Health 6: 519–528
Bank WJ, Pleasure DE, Suzuki K, Nigro M, Katz R (1972) Thallium poisoning. Arch Neurol 26: 456–464
Bruning JL, Kintz BL (1977) Computational handbook of statistics, 2nd Ed, Sott, Foresman & Co., Glenview, Ill.
Cavanagh JB, Fuller NH, Johnson HRM, Rudge F (1974) The effect of thallium salts with particular reference to nervous system changes. A report of three cases. Q J Med 43: 293–319
Chan PH, Yurko M, Fishman RA (1982) Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices. J Neurochem 38: 525–531
Christian GD (1969) Medicine, trace metals and atomic absorption spectroscopy. Anal Chem 41: 24A-40A
Glowinski J, Iversen LL (1966) Regional studies of catecholamines in the rat brain. Disposition of 3H-norepinephrine, 3H-dopamine, and 3H-DOPA in various regions of the brain. J Neurochem 13: 655–669
Hasan M, Ali FS (1981) Effect of thallium, nickel and cobalt administration on the lipid peroxidation in different regions of the rat brain. Toxicol Appl Pharmacol 57: 8–13
Hasan M, Ali FS, Tariq M (1978) Levels of dopamine, norepin-ephrine and 5-hydroxytryptamine in different regions of the rat brain in thallium toxicosis. Acta Pharmacol Toxicol 43: 169–173
Prick JJ (1979) Thallium poisoning. In: Handbook of clinical Neurology, Vol 36, pp 239–278
Reed D, Crawley J, Faro SN, Pieper SJ, Kurland LT (1963) Thallotoxicosis, acute manifestation and sequelae. JAMA 183: 516–522
Robb-Smith AHT (1987) Thallium and a pale horse. Lancet 8537: 872
Roby DS, Fein AM, Bennet RH, Morgan LS, Zatuchni J, Lippman MD (1984) Cardiopulmonary effects of acute thallium poisoning. Chest 85: 236–240
Welz B (1976) Atomic spectroscopy, Verlag-Chemie, New York
Willis WD, Grossman RG (1981) Medical neurobiology. C. V. Mosby Co., New York
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ríos, C., Galván-Arzate, S. & Tapia, R. Brain regional thallium distribution in rats acutely intoxicated with Tl2SO4 . Arch Toxicol 63, 34–37 (1989). https://doi.org/10.1007/BF00334631
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00334631