Abstract
The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.
Similar content being viewed by others
References
Arkhipov GN (1967) Induction of cancer of the glandular stomach in rats by 20-methylcholanthrene. Int J Cancer 2:494–499
Arkhipov GN (1970) Induction of cancer by 20-methylcholanthrene in different regions of the rat stomach. Cancer Res 30:2739–2743
Bartfeld H (1977) Immunologische Untersuchungen zum Nachweis der abwehrsteigernden Wirkung von Aristolochiasäure. Arzneim Forsch 27:2297–2298
Bralow SP (1972) Experimental gastric carcinogenesis. Digestion 5:290–310
Bullock FD, Curtis MR (1930) Spontaneous tumors of the rat. J Cancer Res 14:1–115
Druckrey H, Preussmann R, Schmähl D, Müller M (1961) Erzeugung von Magenkrebs durch Nitrosamide an Ratten. Naturwissenschaften 48:165
Druckrey H, Ivankovic S, Afkham J, Blum G (1962) Erzeugung von Lungenkrebs durch Methylnitrosourethan bei intravenöser Gabe an Ratten. Naturwissenschaften 49:451
Druckrey H, Preussmann R, Ivankovic S, Schmähl D (1967) Organotrope carcinogene Wirkungen bei 65 N-Nitroso-Verbindungen an BD-Ratten. Z Krebsforsch 69:102–201
Eisenbrand G, Preussmann R, Schmähl D (1979) Carcinogenicity of N-nitrosoephedrine in rats. Cancer Lett 5:103–106
Firminger HI, Stewart HL (1952) Histopathogenesis of squamous cell carcinoma induced in the forestomach of mice by intramural injection of 20-Methyl-cholanthrene. J Natl Cancer Inst 12:491–505
Gibel W (1968) Zur Morphologie des experimentell erzeugten Ösophaguskarzinoms bei der Ratte. Arch Geschwulstforsch 31:5–17
Habs M, Schmähl D (1979) Chemotherapy studies in autochthonous rat tumors: Carcinomas of the forestomach. J Cancer Res Clin Oncol 95:39–42
Habs M, Deutsch-Wenzel R, Preussmann R, Schmähl D (1978) Induction of gastric tumors in BD-VI rats by single application of N-Methyl-N-nitro-N-nitrosoguanidine in dimethylsulfoxide (DMSO). Z Krebsforsch 91:183–188
Hahn G (1979) Die Osterluzei —Aristolochia clematitis —eine alte Medizinalpflanze. DR MED 8:41–43
Hedwall PR (1961) Einfluß der Aristolochiasäure auf die Nierenfunktionen von Ratten. Naunyn-Schmiedebergs Arch Pharmacol 24:550
Ivankovic S (1978) Carcinogene Wirkung von N-Benzyl-N-Nitrosoharnstoff (BZNH) an BN-Ratten. Z Krebsforsch 91:63–68
Jackson L, Kofman S, Weiss A, Brodovsky H (1964) Aristolochic acid (NSC-50413): Phase I clinical study. Cancer Chemother Rep 42:35–37
Kupchan SM, Doskotch RW (1962) Tumor inhibitors. I. Aristolochic acid, the active principle of Aristolochia indica. J Med Pharm Chem 5:657–659
Kupchan SM, Merianos J (1968) Tumorinhibitoren, 32.Mitteilung. Isolierung und Strukturaufklä-rung neuer Derivate von Aristolochiasäure und Aristolochia indica. J Chem 33:3735–3738
Martincic A (1956) Die toxische Wirkung von Aristolochia clematitis auf die Niere des Pferdes. Zentralbl Allg Pathol 94:402
McCoy GW (1909) A preliminary report on tumors found in wild rats. J Med Res 21:285–296
Méhes J, Decsi L, Varga F, Kovács S (1958) Selektive chemische Ausschaltung der Harnkanälchen I. Ordnung bei Kaninchen. Naunyn-Schmiedebergs Arch Pharmacol 234:548–565
Mengs U, Lang W, Poch JA (1982) The carcinogenic action of aristolochic acid in rats. Arch Toxicol 51:107–119
Möse JR (1963) Versuche über die Wirksamkeit von Aristolochiasäure. Planta Med 11:72–91
Möse JR (1967) Wirkungsweise der Aristolochiasäure. Therapiewoche 17:1727–1733
Möse JR (1975) The effect of aristolochic acid on the development of methyl-cholanthrene tumours in mice. Osterr Z Onkol 2:151–153
Möse JR, Lukas G (1961) Versuche über die Wirkungsweise von Aristolochia clematitis L. Arzneim Forsch 11:33–36
Möse JR, Porta J (1974) Weitere Studien über Aristolochiasäure. Arzneim Forsch 24:52–54
Moretti C, Rideau M, Chénieux JC, Viel C (1979) Isolement de l'acide aristolochique de deux aristoloches malgaches. Détermination de sa cytotoxicité sur cellules végétales. Comparaison avec les cellules animales. Planta Med 35:360–365
Pakrashi A, Chakrabarty B (1978) Antifertility effect of aristolic acid from Aristolochia indica (Linn) in female albino rabbits. Experientia 34:1377
Pakrashi A, Shaha C, Pal A (1980) Effect of aristolic acid on decidual cell reaction in pseudopregnant mice before and after estrogen surge. IRCS Med Sci 8:553
Peters G, Hedwall PR (1963) Aristolochic acid intoxication: a new type of impairment of urinary concentrating ability. Arch Int Pharmacodyn 145:334–355
Ratcliffe HL (1940) Spontaneous tumors in two colonies of rats of the wistar institute of anatomy and biology. Am J Pathol 16:237–255
Schimmer O, Abel G, Robisch G, Göggelmann W (1982) Vergleich der genotoxischen Aktivität von Aristolochiasäure in verschiedenen Testsystemen. Planta Med 45:136
Schoental R (1960) Carcinogenic action of diazomethane and of Nitroso-N-methyl-urethane. Nature 188:420–421
Schoental R (1966) Carcinogenic activity of N-Methyl-N-nitroso-N-nitroguanidine. Nature 209:726–727
Schoental R, Bensted JPM (1969) Gastrointestinal tumours in rats and mice following various routes of administration of N-Methyl-N-nitroso-N-nitroguanidine and N-Ethyl-N-nitroso-N-nitroguanidine. Br J Cancer 23:757–764
Schvartzman JB, Krimer DB, Moreno Azorero R (1977) Cytological effects of some medicinal plants used in the control of fertility. Experientia 33:663–665
Stewart HL (1967) The Harold Dorn Memorial Lecture. Site variation of alimentary tract cancer in man and experimental animals as indicators of diverse etiology. UICC Monograph Series, vol 9. Springer, Berlin Heidelberg New York, pp 15–49
Stewart HL, Lorenz E (1949/50) Morbid anatomy, histopathology, and histopathogenesis of forestomach carcinoma in mice fed carcinogenic hydrocarbons in oil emulsions. J Natl Cancer Inst 10:147–166
Thiele KG, Muehrcke RC, Berning H (1967) Nierenerkrankungen durch Medikamente. Dtsch Med Wochenschr 92:1632–1635
Thomas C, Schmähl D (1963) Zur Morphologie der durch intravenöse Injektion von Nitrosomethylurethan erzeugten Lungentumoren bei der Ratte. Z Krebsforsch 65:294
Thomas C, So BT (1969) Zur Morphologie der durch N-Nitroso-Verbindungen erzeugten Tumoren im oberen Verdauungstrakt der Ratte. Arzneim Forsch 19:1077–1081
Toledo JD (1965) Die Cytogenese des Vormagencarcinoms der Ratte durch N-Methyl-N-Nitrosourethan. Beitr Pathol Anat 131:63–120
Warzok R, Thust R, Mendel J, Schwarz H, Blaufuss EM (1978) Methylnitrosophenylurea — A highly carcinogenic compound. Cancer Lett 4:299–303
Weisburger JH, Weisburger EK, Mantel N, Hadidian Z, Fredrickson F (1966) New carcinogenic nitrosamines in rats. Naturwissenschaften 53:508
Wolley PG, Wherry WB (1911) Notes on twenty-two spontaneous tumors in wild rats (M. norvegicus). J Med Res 25:205–215
Yasumoto T (1978) Studies on N-Butyl-N-nitrosourethan-induced cancers of the esophagus and the forestomach of rats. Nippon Geka Hokan 47:156–158
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mengs, U. On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Arch Toxicol 52, 209–220 (1983). https://doi.org/10.1007/BF00333900
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00333900