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A reevaluation of the genetic mechanism governing phase variation in Salmonella

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Summary

Synthesis of phase-1 antigen is blocked through a repressor produced under the control of a regulator gene situated in the H 2 operon. If the operator gene ah 2 undergoes an operator-negative mutation, the transcription of operon H 2 is inhibited. As a consequence the operator gene ah 1 situated in the H 1 operon becomes derepressed and synthesis of phase-1 antigen occurs.

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References

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Authors and Affiliations

  1. Cantacuzino Institute, Bucharest, Romania

    Richard Klein

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  1. Richard Klein
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Communicated by F. Kaudewitz

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Klein, R. A reevaluation of the genetic mechanism governing phase variation in Salmonella . Molec. Gen. Genetics 107, 114–116 (1970). https://doi.org/10.1007/BF00333627

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  • DOI: https://doi.org/10.1007/BF00333627

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