Abstract
A purified batch of the artificial sweetener saccharin (S-1022) was assayed for mutagenicity and comutagenicity by the Ames Salmonella assay system. Saccharin was not mutagenic and failed to enhance the mutagenic activity induced by a wide variety of known mutagens. These results do not argue against the tumor-promoter-like activity of saccharin but only indicate that the Ames Salmonella assay is not capable of detecting saccharin as a promoter of mutagenesis.
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Research jointly sponsored by the Environmental Protection Agency (IAG-D5-E681; Interagency Agreement 40-516-75) and the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation
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Rao, T.K., Stoltz, D.R. & Epler, J.L. Lack of enhancement of chemical mutagenesis by saccharin in the Salmonella assay. Arch Toxicol 43, 141–145 (1979). https://doi.org/10.1007/BF00333621
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DOI: https://doi.org/10.1007/BF00333621