Skip to main content
Log in

Monoamine oxidase inhibitors and the depletion of 5-hydroxytryptamine from enterochromaffin cells by reserpine

  • Published:
Zeitschrift für Zellforschung und Mikroskopische Anatomie Aims and scope Submit manuscript

Summary

The influence of Nialamide (a monoamine oxidase inhibitor) on the depletion of 5-hydroxytryptamine from enterochromaffin cells, has been studied in rabbits. Experimental animals were given varying doses of Nialamide in N/10 HCl by single or repeated injections, followed by injections of reserpine. Control animals were given N/10 HCl followed by reserpine or by reserpine solvent. Nialamide did not prevent the depletion of enterochromaffin cell granules by reserpine in any of the experimental animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Biel, J. H., Horita, A., Drukker, A. E.: Monoamine oxidase inhibitors (hydrazines). In: Psychopharmacological agents, vol. I, ed. M. Gordon, p. 359–443. New York: Academic Press 1964.

    Google Scholar 

  • Feldberg, W.: The monoamines of the hypothalamus as mediators of temperature responses. In: Recent advances in pharmacology', 4th ed., ed. J. M. Robson and R. S. Stacey, p. 349–397. London: Churchill 1968.

    Google Scholar 

  • Funderburk, W. H., Finger, K. F., Drakontides, A. B., Schneider, J. A.: EEG and biochemical findings with MAO inhibitors. Ann. N.Y. Acad. Sci. 96, 289–302 (1962).

    Google Scholar 

  • Pearse, A. G. E.: Personal communication, 1963.

  • Pletcher, A., Shore, P. A., Brodie, B. B.: Serotonin release as a possible mechanism of reserpine action. Science 122, 374–375 (1955).

    Google Scholar 

  • —: Serotonin as a mediator of reserpine action in brain. J. Pharmacol. exp. Ther. 116, 84–89 (1956).

    Google Scholar 

  • Shore, P. A., Mead, J. A. R., Kuntzman, R. G., Spector, S., Brodie, B. B.: On the physiologic significance of monoamine oxidase in brain. Science 126, 1063–1064 (1957).

    Google Scholar 

  • Singh, I.: A new argyrophile method for the rapid staining of enterochromaffin cells in paraffin sections. Acta anat. (Basel) 59, 290–296 (1964).

    Google Scholar 

  • Spector, S., Shore, P. A., Brodie, B. B.: J. Pharmacol. exp. Ther. 128, 15 (1960). Cit. by Biel et al. (1964).

    Google Scholar 

  • Williams, R. J., Lansford, E. M.: The encyclopedia of biochemistry, p. 40. New York: Reinhold 1967.

    Google Scholar 

  • Zbinden, G., Pletscher, A., Studer, A.: Klin. Wschr. 35, 565 (1957). (Cit. by Biel et al., 1964.)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Singh, I. Monoamine oxidase inhibitors and the depletion of 5-hydroxytryptamine from enterochromaffin cells by reserpine. Z. Zellforsch. 117, 73–75 (1971). https://doi.org/10.1007/BF00331102

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00331102

Key-Words

Navigation