Summary
The transmission rules of the mitochondrial genome have been established from the analysis of nucleomorph segregation in several Drosophila mauritiana heteroplasmic strains. The mode of segregation is independent of the nature and the initial frequencies of the nucleomorphs. As predicted from a genetic drift model, the quasicomplete sorting-out will need as many as 500 generations. The number of segregating units, estimated at about 400, fits well the number of mitochondria observed in animal cells.
Similar content being viewed by others
References
Adoutte A, Beisson J (1972) Evolution of mixed populations of genetically different mitochondria in Paramecium aurelia. Nature 235:393–396
Avise JC, Giblin-Davidson C, Laerm J, Patton JC, Lansman RA (1979) Mitochondrial DNA clones and matriarchal phylogeny within and among geographic populations of the pocket gopher, Geomys pinetis. Proc Natl Acad Sci USA 76:6694–6698
Birky CW Jr (1983a) The partitioning of cytoplasmic organelles at cell division. Int Rev Cytol (suppl) 15:49–89
Birky CW Jr (1983b) Relaxed cellular controls and organelle heredity. Science 222:468–475
Birky CW Jr, Strausberg RL, Perlman PS (1978) Vegetative segregation of mitochondria in yeast: estimating parameters using a random model. Mol Gen Genet 158:251–261
Birky CW Jr, Maruyama T, Fuerst P (1983) An approach to population and evolutionary genetic theory for genes in mitochondria and chloroplasts, and some results. Genetics 103:513–527
Brown GG, Des Rosiers LJ (1983) Rat mitochondrial DNA polymorphism: sequence analysis of a hypervariable site for insertions/deletions. Nucl Acids Res 11:6699–6708
Brown GG, Simpson MV (1981) Intra- and interspecific variation of the mitochondrial genome in Rattus norvegicus and Rattus rattus: restriction enzyme analysis of variant mitochondrial DNA molecules and their evolutionary relationships. Genetics 97:125–143
Brown WM (1980) Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis. Proc Natl Acad Sci USA 77:3605–3609
Chapman RW, Stephens JC, Lansman RA, Avise JC (1982) Models of mitochondrial DNA transmission genetics and evolution in higher eucaryotes. Genet Res 40:41–57
Coote JL, Szabados G, Work TS (1979) The heterogeneity of mitochondrial DNA in different tissues from the same animal. FEBS Lett 99:255–260
Crow JF, Kimura M (1970) An introduction to population genetics theory. Harper and Row, New York, p 591
Dawid IB, Blackler AW (1972) Maternal and cytoplasmic inheritance of mitochondrial DNA in Xenopus. Dev Biol 29:152–161
Fauron C M-R, Wolstenholme DR (1980) Intraspecific diversity of nucleotides within the adenine+thymine-rich region of mitochondrial DNA molecules of Drosophila mauritiana, D. melanogaster and D. simulans. Nucl Acids Res 8:5391–5410
Ferris SD, Sage RD, Prager EM, Ritte U, Wilson AC (1983) Mitochondrial DNA evolution in mice. Genetics 105:681–721
Goldring ES, Peacock WJ (1977) Intramolecular heterogeneity of mitochondrial DNA of Drosophila melanogaster. J Cell Biol 73:279–286
Hauswirth WW, Laipis PJ (1982) Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows. Proc Natl Acad Sci USA 79:4686–4690
Hayashi J-I, Yonekawa H, Gotoh O, Watanabe J, Tagashira Y (1978) Strictly maternal inheritance of rat mitochondrial DNA. Biochem Biophys Res Commun 83:1032–1038
Hutchison CA III, Newbold JE, Potter SS, Edgell MH (1974) Maternal inheritance of mammalian mitochondrial DNA. Nature 251:536–538
Lansman RA, Avise JC, Huettel MD (1983) Critical experimental test of the possibility of “paternal leakage” mitochondrial DNA. Proc Natl Acad Sci USA 80:1969–1971
Michaelis P (1959) Cytoplasmic inheritance and the segregation of plasma genes. Proceedings Tenth International Congress of Genetics, vol I. 375–385
Nei M, Tajima F (1981) DNA polymorphism detectable by restriction endonucleases. Genetics 97:145–163
Ojala F, Attardi G (1977) A detailed physical map of HeLa cell mitochondrial DNA and its alignment with the positions of known genetic markers. Plasmid 1:78–105
Potter SS, Newbold JE, Hutchison CA III, Edgell MH (1975) Specific cleavage analysis of mammalian mitochondrial DNA. Proc Natl Acad Sci USA 72:4496–4500
Reilly JG, Thomas CA Jr (1980) Length polymorphism, restriction site variation and maternal inheritance of mitochondrial DNA of Drosophila melanogaster. Plasmid 3:109–115
Robberson DL, Clayton DA, Morrow JF (1974) Cleavage of replicating forms of mitochondrial DNA by EcoRI nuclease. Proc Natl Acad Sci USA 71:4447–4451
Solignac M, Monnerot M, Moulonou J-C (1983) Mitochondrial DNA heteroplasmy in Drosophila mauritiana. Proc Natl Acad Sci USA 80:6942–6946
Stevens BJ (1977) Variation in number and volume of the mitochondria in yeast according to growth conditions. A study based on serial sectioning and computer graphics reconstitution. Biol Cellulaire 28:37–56
Takahata N, Maruyama T (1981) A mathematical model of extranuclear genes and the genetic variability maintained in a finite population. Genet Res 37:291–302
Tsacas L, David J (1974) Drosophila mauritiana n.sp. du groupe melanogaster de l'île Maurice (Dipt. Drosophilidae). Bull Soc Entomol Fr 79:42–46
Upholt WB, Dawid IB (1977) Mapping of mitochondrial DNA of individual sheep and goats: rapid evolution in the D loop region. Cell 11:571–583
Wright S (1968) Evolution and the genetics of populations, vol 2. University of Chicago Press, Chicago, Illinois
Author information
Authors and Affiliations
Additional information
Communicated by F. Kaudewitz
Rights and permissions
About this article
Cite this article
Solignac, M., Génermont, J., Monnerot, M. et al. Genetics of mitochondria in Drosophila: mtDNA inheritance in heteroplasmic strains of D. mauritiana . Mol Gen Genet 197, 183–188 (1984). https://doi.org/10.1007/BF00330961
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00330961