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Cellular kinetics of the peripheral nerve and striated muscle after a single dose of X-rays

A histological and autoradiographical study, using 3H-thymidine

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Summary

Thirtysix mice were irradiated with a single dose of X-rays (2760 rad) on one leg, while the rest of the body was shielded by lead. The animals were killed 1–270 days after the irradiation and 3H-thymidine was injected 2 hours before death. Sections from the sciatic nerve and its innervated muscles were examined by autoradiography and by special methods for the mast cells. No changes in the endoneurial mast-cell component could be disclosed after irradiation. At all times after the irradiation, the numbers of labelled Schwanncell nuclei and the sarcolemna-cell nuclei were moderately decreased on the irradiated side, when compared with the control side.

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Supported by a grant from the Swedish Medical Research Council.

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Hassler, O. Cellular kinetics of the peripheral nerve and striated muscle after a single dose of X-rays. Zeitschrift für Zellforschung 85, 62–66 (1967). https://doi.org/10.1007/BF00330586

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