Abstract
The dominant suppressor Su(var)b 101 and the dominant enhancer En(var)c 101 were found to affect significantly white variegation in a strongly variegating line of the w m4chromosome (w m4h) which has been used as standard rearrangement for a genetic dissection of position-effect variegation (Reuter and Wolff, 1981). Both mutations were also shown to affect position-effect heterochromatisation in T(1;4)w m258-21and variegation in all the rearrangements tested (white, brown, scute and bobbed variegation). These results suggest that the genes identified encode functions essential for the manifestation of gene inactivation in position-effect rearrangements. It seems also reasonable to assume that in all the rearrangements tested identical heterochromatisation processes lead to inactivation of the genes whose phenotype is variegated.
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Ananiev, E.V., Gvozdev, V.A.: Changed pattern of transcription and replication in polytene chromosomes of Drosophila melanogaster resulting from eu-heterochromatin rearrangement. Chromosoma (Berl.) 45, 173–191 (1974)
Baker, W.K.: Position-effect variegation. Adv. Genet. 14, 133–169 (1968)
Baker, W.K.: Evidence for position-effect suppression of the ribosomal RNA cistrons in Drosophila melanogaster. Proc. Natl. Acad. Sci. (Wash.) 68, 2472–2476 (1971)
Cowell, J.K., Hartmann-Goldstein, I.J.: Modification of the DNA content in translocated regions of Drosophila polytene chromosomes. Chromosoma (Berl.) 81, 55–64 (1980)
Ephrussi, B., Herold, J.L.: Studies of eye pigments of Drosophila. I. Methods of extraction and quantitative estimation of the pigment components. Genetics 29, 148–175 (1944)
Hartmann-Goldstein, I.J.: On the relationship between heterochromatization and variegation in Drosophila, with special reference to temperature-sensitive periods. Genet. Res. Camb. 10, 143–149 (1967)
Hartmann-Goldstein, I.J., Wargent, J.M.: Cytological observations on the interaction between two inversions responsible for position-effect variegation in Drosophila melanogaster. Chromosoma (Berl.) 52, 349–362 (1975)
Lewis, E.B.: The phenomenon of position effect. Adv. Genet. 3, 73–115 (1950)
Lindsley, D.L., Grell, E.M.: Genetic variations of Drosophila melanogaster. Carnegie Inst. Washington Publ. 627, (1968)
Nix, C.E.: Suppression of transcription of the ribosomal RNA cistrons of Drosophila melanogaster in a structurally rearranged chromosome. Biochem. Genet. 10, 1–12 (1973)
Prokovjeva-Belgovskaya, A.A.: Heterochromatization as a change of chromosome cycle. J. Genet. 48, 80–98 (1947)
Reuter, G., Wolff, I.: Isolation of dominant suppressor mutations for position-effect variegation in Drosophila melanogaster. Mol. Gen. Genet. 182, 516–519 (1981)
Slatis, M.M.: Position effects at the brown locus in Drosophila melanogaster. Genetics 40, 5–23 (1955)
Sorsa, V., Green, M.M., Beermann, W.: Cytogenetic fine structure and chromosomal localization of the white gene in Drosophila melanogaster. Nature New Biol. 245, 34–37 (1973)
Spofford, J.B.: Single-locus modification of position-effect variegation in Drosophila melanogaster. I. White variegation. Genetics 57, 751–766 (1967)
Spofford, J.B.: Position-effect variegation in Drosophila. In: The genetics and biology of Drosophila (M. Ashburner and E. Novitski, eds.), Vol. 1 c, pp. 955–1018. London, New York, San Francisco: Academic Press, 1976
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Reuter, G., Werner, W. & Hoffmann, H.J. Mutants affecting position-effect heterochromatinization in Drosophila melanogaster . Chromosoma 85, 539–551 (1982). https://doi.org/10.1007/BF00327349
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DOI: https://doi.org/10.1007/BF00327349