Skip to main content

Advertisement

Log in

Renal oncocytoma

  • Published:
World Journal of Urology Aims and scope Submit manuscript

Summary

A decade has now passed since “renal oncocytoma” became a diagnosis of acute interest to urologists, radiologists and pathologists. The number of patients with renal oncocytoma continues to increase; now a total of over 340 reported cases are available for analysis. Approximately 3% of tumors previously diagnosed as renal cell carcinomas are now considered to be renal oncocytomas. The overwhelmingly benign clinical behavior of typical renal oncocytomas seems well established. At present, there is no definitive way to make the diagnosis of renal oncocytoma preoperatively. Because renal oncocytomas are not so rare, clinicians dealing with solid renal tumors must keep in mind this diagnosis and its possible bilateral and multifocal occurrence. Conservative renal parenchyma sparing operations for oncocytomas should be encouraged.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Akhtar M, Kott E (1979) Oncocytoma of kidney. Urology 14:397–400

    Google Scholar 

  2. Alanen KA, Ekfors TO, Lipasti JA, Nurmi MJ (1984) Renal oncocytoma: the incidence of 18 surgical and 12 autopsy cases. Histopathology 8:731–737

    Google Scholar 

  3. Ambos MA, Bosniak MA, Valensi QJ, Madayag MA, Lefleur SS (1978) Angiographic patterns in renal oncocytomas. Radiology 129:615–622

    Google Scholar 

  4. Arnold BM, Kovacs K, Horvath E, Murray TM, Higgins HP (1974) Functioning oxyphil cell adenoma of the parathyroid gland: evidence for secretory activity of oxyphil cells. J Clin Endocrinol Metab 38:458–462

    Google Scholar 

  5. Auvert J, Abbou CC, Lavarenne V (1982) Needle tract seeding following puncture of renal oncocytoma. Prog Clin Biol Res 100:597–598

    Google Scholar 

  6. Ball DS, Friedman AC, Hartman DS, Radecki PD, Caroline DF (1986) Scar sign of renal oncocytoma: magnetic resonance imaging appearance and lack of specificity. Urol Radiol 8:46–48

    Google Scholar 

  7. Barnes CA, Beckman EN (1983) Renal oncocytoma and its congeners. Am J Clin Pathol 79:312–318

    Google Scholar 

  8. Barth KH, Menon M (1980) Renal oncocytoma: further diagnostic observations. Diagn Imaging 49:259–265

    Google Scholar 

  9. Batsakis JG, Martz DG (1960) Oxyphil cell tumor of submaxillary gland. US Armed Forces Med J 14:1383–1386

    Google Scholar 

  10. Bazaz-Malik G, Gupta DN (1968) Metastasizing (malignant) oncocytoma of the parotid gland. Z Krebsforsch 70:193–197

    Google Scholar 

  11. Behari R, Green JA, Maharaj R, Khan R (1985) Renal oncocytoma: a report of 3 cases. S Afr Med J 67:182–183

    Google Scholar 

  12. Bell ET (1950) Renal diseases 2nd ed. Lea and Febiger, Philadelphia, p 428

    Google Scholar 

  13. Bennington JL, Mayall BH (1983) DNA cytometry on four-micrometer sections of paraffin-embedded human renal adenocarcinomas and adenomas. Cytometry 4:31–39

    Google Scholar 

  14. Bennington JL (1973) Cancer of the kidney. Etiology, epidemiology and pathology. Cancer 32:1017–1029

    Google Scholar 

  15. Berger G, Clermont A, Pinet F, Loire R (1973) Pluricentric oncocytoma of the kidney (microangiographic study). Arch Anat Pathol (Paris) 21:287–292

    Google Scholar 

  16. Black WC III (1969) Pulmonary oncocytoma. Cancer 23:1347–1357

    Google Scholar 

  17. Blank C, Eneroter C, Jakobssin P (1970) Oncocytoma of the parotid gland: neoplasm or nodular hyperplasia. Cancer 25:919–925

    Google Scholar 

  18. Blessing MA, Wienert G (1973) Onkozytom der Niere. Zentrabl Allg Pathol 117:227–234

    Google Scholar 

  19. Bokinsky GB (1981) Renal oncocytoma. Urology 17:364–366

    Google Scholar 

  20. Bonavita JA, Pollack HM, Banner MP (1981) Renal oncocytoma: further observations and literature review. Urol Radiol 2:229–234

    Google Scholar 

  21. Bono AV, Caresano A, Roggia A, Gianneo E (1980) A case of renal oncocytoma. Eur Urol 6:247–248

    Google Scholar 

  22. Briggs J, Evans JNG (1967) Malignant oxyphilic granular-cell tumor (oncocytoma) of the palate. Oral Surg 23:796–802

    Google Scholar 

  23. Cavaliere A, Bacci M, Pancotti G, de Santis G (1984) A case of proximal tubular adenoma (oncocytoma) of the kidney. Pathologica 76:263–268

    Google Scholar 

  24. Chaudhry AP, Slotkin E, Satchidanand SK, Shenoy S, Gaeta JF, Nickerson PA (1979) Light and ultrastructural studies of renal oncocytic adenoma. Urology 14:392–396

    Google Scholar 

  25. Chen KTK (1983) Multiple renal oncocytoma. J Urol 130:546–547

    Google Scholar 

  26. Chesky VE, Dreese WC, Helwig CA (1951) Hurthle cell tumors of the thyroid gland: report of 25 cases. J Clin Endocrinol Metabol 11:1535–1548

    Google Scholar 

  27. Choi H, Almagro UA, McManus JT, Norback DH, Jacobs SC (1983) Renal oncocytoma: a clinicopathologic study. Cancer 51:1887–1896

    Google Scholar 

  28. Cohan RH, Dunnick NR, Degesys GE, Korobkin M (1984) Computed tomography of renal oncocytoma. J Comput Assist Tomogr 8:284–287

    Google Scholar 

  29. Cooper PH, Waisman J (1973) Tubular differentiation and basement membrane production in a renal adenoma: Ultrastructural features. J Pathol 109:113–121

    Google Scholar 

  30. de Corral LV, Quintero EC, Manich BV (1984) Renal oncocytoma: case report. Bol Asoc Med PR 76:20–22

    Google Scholar 

  31. Demos TC, Schiffer M, Love L, Waters WB, Moncada R (1985) Normal excretory urography in patients with primary kidney neoplasms. Urol Radiol 7:75–79

    Google Scholar 

  32. Eble JN, Hull MT (1984) Morphologic features of renal oncocytoma: a light and electron microscopic study. Hum Pathol 15:1054–1061

    Google Scholar 

  33. Eble JN, Sledge G (1986) Cellular deoxyribonucleic acid content of renal oncocytomas: flow cytometric analysis of paraffin-embedded tissues from eight tumors. J Urol 136:522–524

    Google Scholar 

  34. Ejeckam G, Tolnai G, Sarkar K, McCaughey WTE (1979) Renal oncocytoma: study of eight cases. Urology 14:186–189

    Google Scholar 

  35. Fairchild TN, Dail DH, Brannen GE (1983) Renal oncocytoma: bilateral, multifocal. Urology 22:355–359

    Google Scholar 

  36. Forland M, Bannayan GA (1983) Minimal-change lesion nephrotic syndrome with renal oncocytoma. Am J Med 75:715–720

    Google Scholar 

  37. Frazel EL, Duffy BJ Jr (1951) Hurthle-cell cancer of the thyroid. Cancer 4:952–956

    Google Scholar 

  38. Giuffre BM, Gulliver DJ (1984) Renal oncocytoma. Australas Radiol 28:120–123

    Google Scholar 

  39. Goiney RC, Goldenberg L, Cooperberg PL, Charboneau JW, Rosenfield AT, Russin LD, McCarthy S, Zeman RK, Gordon PB, Rowley BA (1984) Renal oncocytoma: sonographic analysis of 14 cases. AJR 143:1001–1004

    Google Scholar 

  40. Gray SR, Cornog JL, Seo IS (1976) Oncocytic neoplasms of salivary glands: a report of fifteen cases including two malignant oncocytomas. Cancer 38:1306–1317

    Google Scholar 

  41. Hamperl H (1931) Beiträge zur normalen und pathologischen Histologie menschlicher Speicheldrüsen. Z Mikrosk Anat Forsch 27:1–55

    Google Scholar 

  42. Hamperl H (1964) Oncocytomas of different organs. Acta Union Int Cancer 20:854

    Google Scholar 

  43. Hara M, Yoshida K, Tomita M, Akimoto M, Kawai M, Fukuda Y (1982) A case of bilateral renal oncocytoma. J Urol 128:576–578

    Google Scholar 

  44. Harrison RH, Baird JM, Kowierschke SW (1981) Renal oncocytoma: ten-year follow-up. Urology 17:596–599

    Google Scholar 

  45. Horn RC (1954) Hurthle cell tumors of the thyroid. Cancer 7:234–244

    Google Scholar 

  46. Hunt HA, Tudball CF, Sutherland RC, Westmore DD (1983) Bilateral renal oncocytomas: a case report. J Urol 129:1220–1221

    Google Scholar 

  47. Jaffé RH (1932) Adenolymphoma (onkocytoma) of the parotid gland. Am J Cancer 16:1415–1423

    Google Scholar 

  48. Jasinski RW, Amendola MA, Glazer GM, Bree RL, Gikas PW (1985) Computed tomography of renal oncocytomas. Comput Radiol 9:307–314

    Google Scholar 

  49. Johannessen JV (1979) Electron microscopy in human medicine, vol 9, Urogenital system and breast. McGraw-Hill, New York p 169

    Google Scholar 

  50. Johnson JR, Thurman AE, Metter JB, Bannayan GA (1979) Oncocytoma of kidney. Urology 14:181–185

    Google Scholar 

  51. Kavoussi LR, Torrence RJ, Catalona WJ (1985) Renal oncocytoma with synchronous contralateral renal cell carcinoma. J Urol 134:1193–1196

    Google Scholar 

  52. Kay S, Armstrong KS (1980) Oncocytic tubular adenoma of the kidney: report of three cases with 28-year follow-up in one. In: Fienoglio CM, Wolff M (eds) Progress in Surgical Pathology, vol 2. Mason, New York, pp 259–268

    Google Scholar 

  53. Kendall AR, Pollack HM, Petersen RO, Stein BS (1980) Incidentally found renal mass. J Urol 124:269–273

    Google Scholar 

  54. Klein MJ, Valensi QJ (1976) Proximal tubular adenomas of kidney with socalled oncocytic features: a clinicopathological study of 13 cases of a rarely reported neoplasm. Cancer 38:906–914

    Google Scholar 

  55. Klimberg I, Epstein H, Wajsman Z (1986) Oncocytoma in a horseshoe kidney. J Urol 135:1002–1004

    Google Scholar 

  56. Lafortune M, Breton G (1983) Echographic demonstration of an oncocytoma. J Can Assoc Radiol 34:144–146

    Google Scholar 

  57. Lautin EM, Gordon PM, Friedman AC, McCormick JF, Fromowitz FB, Goldman MJ, Sugarman LA (1981) Radionuclide imaging and computed tomograph in renal oncocytoma. Radiology 138:185–190

    Google Scholar 

  58. Lawrence WT, Bajallan NMS (1985) The importance of recognizing renal oncocytomas. Br J Urol 57:625–629

    Google Scholar 

  59. Lehmann HD, Blessing MH (1982) Renal oncocytoma (pathology, preoperative diagnosis, therapy). Prog Clin Biol Res 100:589–596

    Google Scholar 

  60. Levine E, Huntrakoon M (1983) Computed tomography of renal oncocytoma. AJR 141:741–746

    Google Scholar 

  61. Levy JM, Potter WM (1982) Case of the month no 55. Renal oncocytoma: focal nodular hyperplasia of the liver. Ariz Med 39:250–252

    Google Scholar 

  62. Lewi HJE, Alexander CA, Fleming S (1986) Renal oncocytoma. Br J Urol 58:12–15

    Google Scholar 

  63. Lieber MM, Tomera KM, Farrow GM (1981) Renal oncocytoma. J Urol 125:481–485

    Google Scholar 

  64. Lieber MM (1984) Renal oncocytoma. In: Javadopour N (ed) Cancer of the kidney. Thieme Stratton, New York, pp 154–165

    Google Scholar 

  65. Maatman TJ, Novick AC, Tancino JBF, Vesoulis Z, Levin HS, Montie JE, Montague DK (1984) Renal oncocytoma: diagnostic and therapeutic dilemma. J Urol 132:878–881

    Google Scholar 

  66. Merino MJ, Livolsi VA (1982) Oncocytomas of the kidney. Cancer 50:1852–1856

    Google Scholar 

  67. Milstoc M (1977) Renal oncocytoma: a rare case of renal adenoma. J Urol 118:856–857

    Google Scholar 

  68. Mitchell KM, Shilkin KB (1982) Renal oncocytoma. Pathology 14:75–80

    Google Scholar 

  69. Morales A, Wasan S, Bryniak S (1980) Renal oncocytomas: clinical radiological and histological features. J Urol 123:261–264

    Google Scholar 

  70. Moshman SE, Fromowitz FB, Lautin EM, Gendelman HE (1982) Renal oncocytoma. NY Stat J Med 82:1471–1473

    Google Scholar 

  71. Moura ACF, Nascimento AG (1982) Renal oncocytoma: report of a case with unusual presentation. J Urol 127:311–313

    Google Scholar 

  72. Murphy F, Ghadially FN (1983) Diagnosis of human tumors. Case 3: renal oncocytoma. Ultrastruct Pathol 5:285–289

    Google Scholar 

  73. Nguyen G-K, Amy RW, Tsang S (1985) Fine needle aspiration biopsy cytology of renal oncocytoma. Acta Cytol 29:33–36

    Google Scholar 

  74. Olsen JH, Nielsen OS, Engel U (1984) Neoplasm to neoplasm metastasis. A renal oncocytoma with metastatic bronchogenic carcinoma. Scand J Urol Nephrol 18:255–256

    Google Scholar 

  75. Parenti A, Palma PD, Piazza M (1983) Renal oncocytoma: report of two cases. Tumori 69:271–277

    Google Scholar 

  76. Pearse HD, Houghton DC (1979) Renal oncocytoma. Urology 13:74–77

    Google Scholar 

  77. Poroshin KK, Galyl-Ogly GA (1965) Oncocytic adenomas. Arch Pathol 27:43–49

    Google Scholar 

  78. Porteous PH (1982) Renal oncocytoma [clinical conference]. S Afr J Surg 20:235–236

    Google Scholar 

  79. Quinn MJ, Hartman DS, Friedman AC, Sherman JL, Lautin EM, Pyatt RS, Ho CK, Csere R, Fromowitz FB (1984) Renal oncocytoma: new observations. Radiology 153:49–53

    Google Scholar 

  80. Rainwater LM, Farrow GM, Lieber MM (1986) Flow cytometry of renal oncocytoma: common occurrence of deoxyribonucleic acid polyploidy and aneuploidy. J Urol 135:1167–1171

    Google Scholar 

  81. Rainwater LM, Hosaka Y, Farrow GM, Lieber MM (1987) Well differentiated clear cell renal carcinoma: significance of nuclear deoxyribonucleic acid patterns studied by flow cytometry. J Urol 137:15–20

    Google Scholar 

  82. Raspa RW, Fernandes M, Ward JN (1985) Bilateral renal oncocytoma: report of 2 cases and review of literature. J Urol 133:458–461

    Google Scholar 

  83. Remark RR, Berquist TH, Lieber MM, Charboneau JW, Hartman GW (1987) Magnetic resonance imaging of renal oncocytoma. Urology (in press)

  84. Rodriguez CA, Buskop A, Johnson J, Fromowitz F, Loss LG (1980) Renal oncocytoma: preoperative diagnosis by aspiration biopsy. Acta Cytol 24:355–359

    Google Scholar 

  85. Rosenberg JW (1986) Renal oncocytoma. NY State J Med 83:385–387

    Google Scholar 

  86. Roth SI, Olen E, Hausen LS (1962) The eosinophilic cells of the parathyroid (oxyphil cells), salivary (oncocytes), and thyroid (Hurthle cells) gland: light and electron microscopic observations. Lab Invest 11:933–941

    Google Scholar 

  87. Sarkar K, Ejeckman GC, McCaughey WTE, Tolnai G (1979) Oncocytic tumors of the kidney (so called “renal oncocytomas”). Abstracts, IAP Annual Meeting. Lab Invest 40:282

    Google Scholar 

  88. Säuberli H, Wirth W, Lerf B, Schmucki O (1983) Renal oncocytoma: a rare renal tumor with typical angiographic features. Eur Urol 9:248–251

    Google Scholar 

  89. Shah I, Parekh N, Nakah PK, Taher S (1983) Renal oncocytoma associated with diffuse lymphoma. Urology 22:314–317

    Google Scholar 

  90. Slasky BS, Bron KM (1982) Aneurysms in renal oncocytoma. Urology 20:552–554

    Google Scholar 

  91. Sos TA, Gray G Jr, Baltaxe HA (1976) The angiographic appearance of benign renal oxyphilic adenoma. AJR 127:717–722

    Google Scholar 

  92. Srinivas V, Herr HW, Hajdu EO (1985) Partial nephrectomy for a renal oncocytoma associated with tuberous sclerosis. J Urol 133:263–265

    Google Scholar 

  93. Suherman S, van Biervliet J-P, Maurur C, van de Voorde P, Vergison R, Michielssen P, van Damme B (1985) Multiple renal oncocytoma and bilateral cystic kidney. Eur J Pediatr 144:406–409

    Google Scholar 

  94. Sun CN, White HJ, Thompson BW (1975) Oncocytoma (mitochondriom) of the parotid gland: an electron microscopic study. Arch Pathol 99:208–214

    Google Scholar 

  95. Susman BR, Levin FA, Barland P, Fromowitz F (1981) Vasculitis associated with renal oncocytoma. NY State J Med 81:1501–1503

    Google Scholar 

  96. Syrjänen K, Hjelt L (1978) Ultrastructural characteristics of human renal cell carcinoma in relation to the light microscopic grading. Scand J Urol Nephrol 12:57–65

    Google Scholar 

  97. Talja M, Bondestam S, Mäkinen J, Lehtonen T (1984) Renal oncocytoma: review of literature and report of six cases. Eur Urol 10:107–113

    Google Scholar 

  98. Tandler B, Hutter RVP, Erlandson RA (1970) Ultrastructure of oncocytoma of the parathyroid gland. Lab Invest 23:567–568

    Google Scholar 

  99. Tannenbaum M (1971) Ultrastructural pathology of human renal cell tumors. Pathol Ann 6:249–277

    Google Scholar 

  100. Tessler AN, Kurusu S, Klein MJ, Valensi QJ (1977) Proximal tubular adenoma of kidney. Urology 10:203–206

    Google Scholar 

  101. Thoenes W, Störkel St, Rumpelt HJ (1986) Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 181:125–143

    Google Scholar 

  102. Thompson NW, Dunn EL, Batsakis JG, Nishiyama RH (1974) Hurthle cell lesions of the thyroid gland. Surg Gynecol Obstet 139:555–560

    Google Scholar 

  103. Tremblay G (1969) The oncocytes. In: Baqusz E, Jasmin G (eds) Methods and achievements in experimental pathology vol 4, Karger, Basel, pp 121–140

    Google Scholar 

  104. van der Walt JD, Reid HAS, Risdon A, Shaw JHF (1983) Renal oncocytoma: a review of the literature and report of an unusual multicentric case. Virchows Arch [Pathol Anat] 398:291–304

    Google Scholar 

  105. Warfel KA, Eble JN (1982) Renal oncocytomatosis. J Urol 127:1179–1180

    Google Scholar 

  106. Wasilkowski A, Dabrowski H (1971) Eosinophilic adenoma of the kidney (oncocytoma). Pol Przegl Chir 43:1051–1054

    Google Scholar 

  107. Wasserman NF, Ewing SL (1983) Calcified renal oncocytoma. AJR 141:747–749

    Google Scholar 

  108. Waters DJ, Holt SA, Andres DF (1986) Unilateral simultaneous renal angiomyolipoma and oncocytoma. J Urol 135:568–570

    Google Scholar 

  109. Weedon D, Splatt AJ, Moore WE (1979) Proximal tubular adenoma of the kidney. Aust NZ J Surg 49:250–252

    Google Scholar 

  110. Weiner SN, Bernstein RG (1977) Renal oncocytoma: angiographic features of two cases. Radiology 125:633–635

    Google Scholar 

  111. White MA, Taylor JS, Murugasu R (1985) Renal oncocytoma: a benign tumour on the increase. Med J Aust 143:157–159

    Google Scholar 

  112. Wojtowicz J, Karwowski A, Konkiewicz J, Lukaszewski B (1979) Case report: renal oncocytoma. J Comput Assist Tomogr 3:124–125

    Google Scholar 

  113. Woodard BH, Tannenbaum SI, Mossler JA (1981) Multicentric renal oncocytoma. J Urol 126:247–248

    Google Scholar 

  114. Yu GSM, Rendler S, Herskowitz A, Molnar JJ (1980) Renal oncocytoma: report of five cases and review of literature. Cancer 45:1010–1018

    Google Scholar 

  115. Zhang G, Monda L, Wasserman NF, Fraley EE (1985) Bilateral renal oncocytoma: report of 2 cases and literature review. J Urol 133:84–86

    Google Scholar 

  116. Zippel L (1942) Zur Kenntnis der Onkocyten, Virchows Arch 308:360–382

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lieber, M.M., Hosaka, Y. & Tsukamoto, T. Renal oncocytoma. World J Urol 5, 71–79 (1987). https://doi.org/10.1007/BF00327060

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00327060

Keywords

Navigation