Abstract
The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth retardation of the pups, that the growth inhibiting effect was directly correlated to the length of administration and that the growth inhibiting effect was more pronounced if dEtOT was given close to parturition than if it was given earlier in the pregnancy. In addition, the growth retardation was not due to an effect on the pups but to an effect on their mothers, probably related to inhibition of the emptying mechanisms of the mammary glands, meaning that the pups were insufficiently fed by their mothers immediately after birth.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Åkerlund M, Strömberg P, Forsling M (1979) Primary dysmenorrhea and vasopressin. Br J Obstet Gynaecol 86: 484–487
Åkerlund M, Strömberg P, Forsling ML, Melin P, Vilhardt H (1983) Inhibition of vasopressin effects on the uterus by a synthetic analogue. Obstet Gynecol 62: 309–312
Fuchs AR, Fuchs F, Husslin P (1982) Oxytocin receptors and human parturition: A dual role for oxytocin in the inition of labour. Science 215: 1396–1398
Melin P, Vilhardt H, Larsson L-E, Lindeberg G, Åkerlund M (1981) Inhibitory effect of O-alkylated analogues of oxytocin and vasopressin on human and rat myometrial activity. J Endocrinol 88: 173–180
Melin P (1984) Effects of some oxytocin antagonists on the intramammary pressure in the rat in vivo. Ferring Research Report
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Magnusson, G., Melin, P. The effect of 1-deamino-2-tyr(ethyl) oxytocin upon peri- and postnatal development of the rat: growth retardation of the offspring. Arch Toxicol 57, 246–249 (1985). https://doi.org/10.1007/BF00324786
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00324786