Abstract
A significant increase in plasma corticosterone levels and depletion of ascorbic acid content in adrenal glands occurred in rats between 1 and 5 h after a single dose (50% LD50) of fenitrothion, returning to normal levels within 12 h; brain AChE activity decreased to about 59–43% and significant inhibition of the enzyme was observed for up to 24 h after intoxication. Repeated dosing with fenitrothion (2.5% LD50) for 14 days caused insignificant elevation of plasma corticosterone levels, while brain AChE activity was inhibited to about 19% of control values and uptake of 4-14C-corticosterone in tissues was significantly diminished.
This is a preview of subscription content, log in via an institution to check access.
References
Breckenridge C, Pesant M, Durham HD, Ecobichon DJ (1982) A 30-day toxicity study of inhaled fenitrothion in the albino rat. Toxicol Appl Pharmacol 62: 32–43
Civen M, Brown CB (1974) The effect of organophosphate insecticides on adrenal corticosterone formation. Pest Biochem Physiol 4: 254–260
Clement JG (1985) Hormonal consequences of organophosphate poisoning. Fund Appl Toxicol 5: S61-S77
Frawley J, Hagan EC, Fitzhugh OG (1952) A comparative pharmacological and toxicological study of organic phosphate anticholinesterase compounds. J Pharmacol Exp Ther 105: 156–165
Guillemin R, Clayton GW, Lipscomb HS, Smith JD (1959) Fluorometric measurment of rat plasma and adrenal corticosterone concentration. J Lab Clin Med 53: 830–832
Kokka N (1976) Central muscarinic stimulation of ACTH secretion. Fed Proc 35: 460–461
Kolta MG, Soliman KFA (1981) Tissue distribution of 3H-corticosterone in response to stress. Endokrinologie 77: 179–184
Miyamoto J (1969) Mechanism of low toxicity of Sumithion toward mammals. Res Rev 25: 251–264
Morris DJ, Barnes FW (1967) On the intracellular distribution of 14C-cortisol in rat liver. Biochim Biophys Acta 136: 67–68
Murphy SD (1966) Response of adaptive rat liver enzymes to acute poisoning by organophosphate insecticides. Toxicol Appl Pharmacol 8: 266–276
Osicka-Koprowska A, Lipska M, Wysocka-Paruszewska B (1984) Effects of chlorfenvinphos on plasma corticosterone and aldosterone levels in rats. Arch Toxicol 55: 68–69
Schaffert RS, Kingsley GR (1955) A rapid, simple method for the determination of reduced, dehydro -, and total ascorbic acid in biological material. J Biol Chem 212: 59–68
Szot RJ, Murphy SD (1970) Phenobarbital and dexamethasone inhibition of the adrenocortical response of rats to toxic chemicals and other stresses. Toxicol Appl Pharmacol 17: 761–773
Weil CS (1952) Tables for convenient calculation of median-effective dose (LD50 or ED50) and instruction in their use. Biometrics 8: 249–263
Yamamoto T, Egashira T, Yoshida T, Kuroiwa Y (1982) Increase of adrenal weight in rats by the repeated administration of fenitrothion. Toxicol Lett 11: 187–191
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Osicka-Koprowska, A., Gradowska-Olszewska, I. & Wysocka-Paruszewska, B. Adrenocortical changes and uptake of 4-14C-corticosterone in rats intoxicated with fenitrothion. Arch Toxicol 61, 76–78 (1987). https://doi.org/10.1007/BF00324552
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00324552