Abstract
The toxicity of isopropyl alcohol (IPA) on the tracheal mucosa was studied experimentally with special reference to the recovery process of the organ. The results showed that 400 ppm IPA has an acute effect on the mucociliary system in the tracheal mucosa, and that recovery from such degeneration can occur in 2 weeks. When functional and morphological damage was induced by a higher level (5500 ppm) of IPA, recovery did not occur in 2 weeks. The conclusion is that the present allowable level of IPA is reasonable from the viewpoint of the effects of short-term exposure to IPA on the tracheal mucosa. In addition, a higher level of IPA exposure has longer-term effects on the tracheal mucosa, and workers exposed to such a higher level of IPA vapor should be given careful otolaryngological follow-up observations.
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References
American Conference of Governmental Industrial Hygienist (1980) Documentation of the shreshold limit values. 4th edition. A.C.G.I.H., Cinncinnati, p 238
Ikeoka H, Ohashi Y, Maruoka K, Nakata J, Masutani H, Nakai Y, Horiguchi S, Teramoto K (1984a) Effects of tetrahydrofuran exposure on the ciliary activity and morphology of tracheal epithelium in rabbits. Osaka City Med J 30: 56–67
Ikeoka H, Ohashi Y, Nakata J, Maruoka K, Nakai Y (1984b) The regeneration of the nasal mucosa after the mechanical injury. J Clin Electron Microscopy 17: 652–653
Ikeoka H, Ohashi Y, Maruoka K, Koshimo H, Nakai Y, Onoyama Y (1986) Electron microscopy of the pathological nasal mucosal epithelium induced by irradiation. J Otolaryngol Jpn 88: 1562–1566
Moore GE, Gerner RE, Franklin HA (1967) Culture of normal human leukocytes. JAMA 199: 519–524
Ohashi Y (1984) The function and morphology of respiratory ciliated cells. J Osaka City Med 32: 427–460
Ohashi Y, Nakai Y (1983a) Functional and morphological studies on chronic sinusitis mucous membrane. 1. Decline of ciliary action in chronic sinusitis. Acta Otolaryngol (Stockh) [Suppl] 397: 3–8
Ohashi Y, Nakai Y (1983b) Functional and morphological studies on chronic sinusitis mucous membrane. 2. Functional and morphological pathology of chronic sinusitis mucous membrane. Acta Otolaryngol (Stockh) [Suppl] 397: 11–48
Ohashi Y, Nakai Y (1984) Mucociliary activities in fetal rabbits. Acta Otolaryngol (Stockh) 97: 351–358
Ohashi Y, Nakai Y, Kihara S, Ikeoka H, Takano H, Imoto T (1985) Ciliary activity in patients with nasal allergies. Arch Otorhinolaryngol 242: 141–147
Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Nakata J, Esaki Y, Horiguchi S, Teramoto K (1986a) Degeneration and regeneration of respiratory mucosa of rats after exposure to styrene. J Appl Toxicol 6: 405–412
Ohashi Y, Nakai Y, Koshimo H, Esaki Y (1986b) Ciliary activity in the in vitro tubotympanum. Arch Otorhinolaryngol 243: 317–319
Ohashi Y, Nakai Y, Kihara S, Ikeoka H (1987a) Effects of Staphylococcus aureus on the ciliary activity of the middle ear lining. Ann Otol Rhinol Laryngol 96: 225–228
Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Esaki Y, Horiguchi S, Teramoto K, Nakaseko H (1987b) An experimental study on the acute effects of isopropyl alcohol exposure on the middle ear mucosa. J Appl Toxicol (in press)
Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Esaki Y, Horiguchi S, Teramoto K, Nakaseko H (1987c) An experimental study on the respiratory toxicity of isopropyl alcohol. J Appl Toxicol (in press)
Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Esaki Y, Kato S, Kato M (1987d) Functional pathology of the eustachian tube in an experimental otitis media with effusion following inoculation of bacterial endotoxin. Ann Otol Rhinol Laryngol (in press)
Ohashi Y, Nakai Y, Ikeoka H, Esaki Y, Koshimo H, Onoyama Y (1987e) Mucosal pathology of an experimental otitis media with effusion after X-ray irradiation. Am J Otolaryngol (in press)
Reimer Å (1978) The mucociliary activity of the upper respiratory tract. III. A functional and morphological study on human and animal materials with special reference to maxillary sinus diseases. Acta Otolaryngol (Stockh) [Suppl] 355: 1–20
Sakakura Y (1974) Mucociliary function during experimentally induced rhinovirus infection in man. Ann Otol Rhinol Laryngol 82: 203–211
Santa CR (1974) Tracheal mucous velocity in normal and patients with obstructive lung diseases: effects of turbulatine. Am Rev Respir Dis 109: 458–463
Teramoto K, Horiguchi S (1985) Animal exposure chamber for toxicological studies. Trial experiments using styrene vapor. J Science Labour 61: 11–18
Treon JF, Stasik MJ (1983) Encyclopedia of occupational health and safety. ILO, Geneva, p 109
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Ohashi, Y., Nakai, Y., Ikeoka, H. et al. Recovery process of tracheal mucosa of guinea pigs exposed to isopropyl alcohol. Arch Toxicol 61, 12–20 (1987). https://doi.org/10.1007/BF00324542
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DOI: https://doi.org/10.1007/BF00324542