Summary
Mixing studies using activated partial thromboplastin time (APTT) technique were performed on 14 patients with lupus-like anticoagulants (LLACs) using human, equine, bovine, porcine and canine plasma. Eleven patients significantly prolonged the APTT of normal human plasma (patient/control ratio=>1.15) but no patient inhibited bovine plasma. However, with one exception, equine APTT ratios were concordant with human ratios. Seven of fourteen patients also inhibited porcine plasma but in each case porcine APTT ratios were lower than their human or equine counterparts. None of five patients tested inhibited canine plasma. Collectively, these results suggest heterogeneity among LLACs at least with regard to species specificity.
Similar content being viewed by others
References
Clyne LP, Dainiak N, Hoffman R, Hardin JA (1980) In vitro correction of anticoagulant activity and specific clotting factor assays. Thromb Res 18: 643–655
Clyne LP, Honig CL, Dainiak N (1984) Correction of clotting factor “deficiencies” in plasma from patients with lupus-like anticoagulants. Thromb Haemost 51: 317–320
Coots MC, Miller MA, Glueck HI (1981) The lupus inhibitor: a study of its heterogeneity. Thromb Haemost 46: 734–739
Exner T, Rickard KA, Kroneberg H (1978) A sensitive test demonstrating lupus anticoagulant and its behavioural patterns. Br J Haematol 40: 143–151
Exner T (1985) Similar mechanism of various lupus anticoagulants. Thromb Haemost 53: 15–18
Hougie C (1964) Naturally occuring species specific inhibitor of human prothrombin in lupus erythematosus. Proc Soc Exp Biol Med 116: 359–361
Kelsey PR, Stevenson KJ, Poller L (1984) The diagnosis of lupus anticoagulants by the activated partial thromboplastin time — the central role of phosphatidyl serine. Thromb Haemost 52: 172–175
Mannucci PM, Canciani TM, Mari D, Meucci P (1979) The varied sensitivity of partial thromboplastin and prothrombin time reagents in the demonstration of the lupus-like anticoagulant. Scan J Haematol 22: 423–432
Schleider MA, Nachman RL, Jaffe EA, Coleman MA (1976) A clinical study of the lupus anticoagulant. Blood 48: 499–509
Veltkamp JJ, Kerkoven P, Loeliger EA (1973/1974) Circulating anticoagulant in disseminated lupus erythematosus. Proposed mode of action. Haemostasis 2: 253–259
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Clyne, L.P. Species specificity of lupus-like anticoagulants. Blut 53, 287–292 (1986). https://doi.org/10.1007/BF00320886
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320886