Abstract
Lupus anticoagulants are antibodies directed to phospholipids (PL) and in particular represent an in vitro phenomenon where these antibodies bind to PL in coagulation reagents creating an artificial prolongation of the activated partial thromboplastin time (APTT) and sometimes also prothrombin time (PT) clotting times. Prolongation of LA-induced clotting times is typically not associated with bleeding risk. However, the degree of prolongation may cause some trepidation for clinicians that will be performing delicate surgeries or those with high bleeding risks, so a mechanism to alleviate their anxiety may be prudent. As such, an autoneutralizing method to mitigate or eliminate the LA effect on the PT and APTT may be beneficial. In this document, the detailing of an autoneutralizing procedure to diminish the LA effect on the PT and APTT will be provided.
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Abbreviations
- APTT:
-
activated partial thromboplastin time
- F2–F12:
-
factor II–factor XII activity
- FBG:
-
fibrinogen
- INR:
-
International Normalized Ratio
- IQC:
-
Internal Quality Control
- LA:
-
Lupus anticoagulant
- PL:
-
phospholipid
- PPP:
-
platelet-poor plasma
- PRP:
-
platelet-rich plasma
- PT:
-
prothrombin time
- RI:
-
reference interval
- s:
-
seconds
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Conflicts of Interest
RCG receives consulting fees from Sysmex America Inc.
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Gosselin, R.C. (2023). An Acute Need Inspiration: Autoneutralization of Lupus Anticoagulants in Affected Prothrombin Times (PT) and Activated Partial Thromboplastin Times (APTT). In: Favaloro, E.J., Gosselin, R.C. (eds) Hemostasis and Thrombosis. Methods in Molecular Biology, vol 2663. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3175-1_18
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DOI: https://doi.org/10.1007/978-1-0716-3175-1_18
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