Summary
The kinetics and distribution in vivo of 111In-labelled platelets prior to and during intravenous high-dose gamma globulin therapy in a 3-months-old child with idiopathic thrombocytopenic purpura were evaluated.
Concomitantly with a prompt increase in platelet concentration we found evidence for release of platelets into the circulation, presumably to a large extent originating from the spleen and liver. Our results support the concept that, in response to high-dose gamma globulin therapy, platelets are not only forced to remain in but are also released into the circulation, presumably as a result of mobilization of platelets adhering to cells of the monocyte-macrophage system.
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Schmidt, K.G., Rasmussen, J.W., Diederichsen, H. et al. Release of platelets into the circulation induced by gamma globulin treatment in a case of idiopathic thrombocytopenic purpura. Blut 48, 27–31 (1984). https://doi.org/10.1007/BF00320714
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DOI: https://doi.org/10.1007/BF00320714