Summary
Two preparations of human interferon (IFN)-α were assessed for their influence on granulocyte-macrophage progenitor cells (CFU-GM) in vitro. Both highly purified human IFN-α Ly and recombinant IFN-α 2a suppressed CFU-GM colony formation in a dose-dependent manner using low-density bone-marrow target cells. Suppression of CFU-GM colony formation was accompanied by an increase in clusters. However, depletion of monocytes, T lymphocytes and B lymphocytes from low-density bone-marrow cells resulted in insensitivity of progenitor cells to IFN-α. These results demonstrate that the effects of human IFN-α on myeloid progenitor cells (CFU-GM) are mediated by accessory cells within the bone marrow.
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Schwamborn, J.S., Nickels, R.M., Katthagen, B.D. et al. Effects of human α-interferon on granulocyte-macrophage progenitor cells (CFU-GM) in vitro. Blut 56, 107–109 (1988). https://doi.org/10.1007/BF00320013
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DOI: https://doi.org/10.1007/BF00320013