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Effect of Apoptotic Neutrophils on the Production of Erythropoietin, MMP-9, and TIMP-1 in Cultures of Human Macrophages

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We studied the effect of apoptotic neutrophils on the production of erythropoietin, MMP-9, and TIMP-1 by GM-CSF-induced human macrophages. GM-CSF-induced macrophages spontaneously produce erythropoietin and secrete MMP-9 and TIMP-1. Polarization of these macrophages towards the M2-like phenotype after exposure to apoptotic neutrophils considerably increased the production of erythropoietin; the MMP-9/TIMP-1 ratio tended to increase under these conditions due to a decrease in TIMP-1.

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Authors and Affiliations

  1. Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia

    L. V. Sakhno, E. Ya. Shevela, A. A. Ostanin & E. R. Chernykh

  2. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Novosibirsk, Russia

    A. P. Lykov & O. V. Poveshchenko

Authors
  1. L. V. Sakhno
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  2. E. Ya. Shevela
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  3. A. P. Lykov
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  4. O. V. Poveshchenko
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  5. A. A. Ostanin
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  6. E. R. Chernykh
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Corresponding author

Correspondence to L. V. Sakhno.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 6, pp. 713-716, June, 2019

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Sakhno, L.V., Shevela, E.Y., Lykov, A.P. et al. Effect of Apoptotic Neutrophils on the Production of Erythropoietin, MMP-9, and TIMP-1 in Cultures of Human Macrophages. Bull Exp Biol Med 167, 755–758 (2019). https://doi.org/10.1007/s10517-019-04616-8

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  • DOI: https://doi.org/10.1007/s10517-019-04616-8

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