Summary
Experimental overgrowth was produced in chick embryo brains according to the method described earlier (1955, 1959). Pieces of overgrown mesencephalic tissue were cultured in vitro or studied with transplantations to the braincavity of host embryos.
When cultured in vitro, cell strands developed in some cultures, showing differences in growth rate and capacity of fibrinolytic activity as compared with normal neural epithelium.
After transplantation to the brain-cavity, one case out of six showed a well delimited tumorous formation of a very benign appearance. In the other five cases, the graft tissue had completely merged with the host tissue, showing invasion into the latter. Numerous mitoses were seen and lots of rosette formations. It is concluded that the overgrowth cells may show a strong tendency to invade brain tissue.
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The cost of this investigation was defrayed by a grant from the Swedish Medical Research Council.
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Källén, B. Studies on experimentally produced overgrowth in chick embryo brain, using tissue culture and transplantation techniques. Z. Zellforsch. 50, 361–368 (1959). https://doi.org/10.1007/BF00319952
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DOI: https://doi.org/10.1007/BF00319952